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Ever since arbovirus infections became known and their relative importance assessed, experiments were designed to elucidate the mode of transmission and the most important natural hosts responsible for perpetuating the infection in nature. Human infections and the disease in wild rodents, birds, and domestic animals were studied in relation to viremia and distribution of the infectious agent in the organism. With increasing epidemiological studies it became apparent that the neural manifestations of the disease are very uncommon, confined only to a small percentage of individuals of the most susceptible species. Various factors have been proposed to explain why in certain instances the virus becomes establish ed in the central nervous system and causes a serious or lethal disease. For example, differences in the virulence of the virus strains, varying susceptibility of individuals of one species, or intercurrent circumstances facilitating access of the virus to the central nervous system were alleged. Also, various possible routes of entry of the virus into the brain and spinal cord have been considered.
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This book provides an evidence-based approach to the diagnosis and surgical management of the diseases of the pancreas and biliary tree, highlighting the most recent findings. The chapters are designed to accompany the reader on a step-by-step approach to the patient, providing the latest evidence to justify each recommendation. Wherever feasible and indicated, emphasis is placed on the use of tables and algorithms to simplify decision-making. The information contained in this well-referenced book is thus relevant not only to practicing pancreatobiliary and general surgeons, but also offers valuable guidance for surgical trainees. This book covers 14 diseases of the pancreas and biliary tree, from the more common gallstones and common bile duct stones, acute and chronic pancreatitis, to more complex benign conditions such as biliary fistulae and strictures, as well as cystic tumors of the pancreas, and finally the major malignancies include gallbladder cancer, pancreatic cancer and hilar cholangiocarcinoma.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.