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National Library of Medicine Current Catalog
First multi-year cumulation covers six years: 1965-70.
Familial Cancer Management
Familial Cancer Management addresses familial cancer patterns, a rapidly expanding field of investigation resulting from recent significant advances in molecular genetics. It encompasses etiological and pathological aspects of familial cancer clustering, the description of frequent and important family syndromes, diagnostic procedures, and principles of counseling, prevention, and management. This unique and thorough text also discusses important ethical and legal issues and identifies familial cancer assessment services. Familial Cancer Management is written for health care professionals enabling them to identify and manage familial cancer occurrences.
Genes in Development
In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a...
Familial Cancer and Prevention
A New Strategy Toward Cancer Control. Still in its infancy, the familial/hereditary approach to cancer control is proving to be one of the most potent strategies in the war on cancer. Over the past few years the human genome project has generated an abundance of valuable information on the genetic origins of a range of cancers. Tests now exist for several hereditary, tumor-promoting genetic mutations-including those found in BRCA genes associated with breast cancer as well as mutations of HNPCC genes which have been linked to colon cancers-and many more are anticipated in the near future. Armed with the information yielded by these tests, physicians have already saved countless lives through...
Progress in Drug Research
In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre clinical investigations. The series' aim was to give coverage to impor tant areas of research, to introduce new active substances with thera peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the resear...
Environmental Politics and Liberation in Contemporary Africa
Nowadays, the environment looms large in the analysis of conflict in developing societies, and the precise role it plays is the subject of an ongoing debate. The de bate has moved on from the earlier, but still popular, notions of 'power struggles', 'class struggles' and 'ethnic conflicts', to a perception of conflict as the product of intense group competition for resources. Where the state controls the distribu tion of resources, itself inevitably becomes party to conflicts whose bone of con tention is access to state power as the most efficient means of gaining access to resources. The resources in question are social (health, education, transportation, communication, recreation, etc. ) a...
Interdisciplinary Approaches to Gene Therapy
Current therapies for most human genetic diseases are inadequate. In response to the need for effective treatments, modern molecular genetics is providing tools for an unprecedented new approach to the treatment of diseases; e.g. the direct manipulation of mutant genes or the input on new therapeutic genes. The treatment of human disease by gene transfer has now moved from the theoretical to the practical realm. With the initiation of clinical trials involving somatic gene therapy in different countries, a critical assessment of the different aspects involved with this new technique is necessary. This volume provides an overview on all these interdisciplinary aspects by some well known experts all over the world.
The future of DNA
The rapid progress in biological and biomedical sciences in the last twenty years has brought with it an extensive development of the methods of molecular genetics. This has had impacts on society in many fields. Practical applications in medicine, pharmacology, agriculture, food design and biotechnology are firmly established and will grow enormously in the years to come. The scientific views of DNA and genes which underpin these applications are challenging our fundamental concepts of life, nature, society and humanity. It is beyond doubt that these developments need to be evaluated and reflected upon, both from a scientific and philosophical point of view, as well as from a cultural and s...
GenEthics and Religion
Human gene and cell technology is a diverse and rapidly evolving field of research. As genes represent the 'blueprint' of an organism, their analysis and manipulation is a challenge to our understanding of human nature. Stem cell research, genetic testing, gene therapy, therapeutic and reproductive cloning -- all these fields of application have been raising fundamental ethical and religious-theological questions: When does human life begin? Should human beings be allowed to interfere with natural procreation or to manipulate the genome of their own species? Is genetic engineering tantamount to 'playing God'? Based on the symposium 'GenEthics and Religion' held in Basel, Switzerland in May 2...
The Decision Trap
The Decision Trap questions a dogma of our time: the assumption that genetic education empowers citizens and increases their autonomy. It argues that professional instructions about genes, genetic risks, and genetic test options convey a genetic worldview which destroys self-confidence and makes clients dependent on genetic experts and technologies. Part one of the book introduces the reader to the idea of genetic education. It clarifies the notion of the "gene" as it is commonly understood, and shows that, scientifically, the concept of genes as definable, causal agents is outdated. Part two of the book investigates the hidden curriculum of genetic education, using genetic counselling as a prime example. Genetic counselling is a professional service that aims to enable clients to make autonomous decisions about genetic test options and cope with the results.
