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Nanotoxicology in Safety Assessment of Nanomaterials
Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs’ specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex ...
30 years of the Comet Assay: an overview with some new insights
By means of this ‘Frontiers in Genetics’ research topic, we are celebrating 30 years of the Comet Assay. The first paper on this single-cell gel electrophoresis assay was published in 1984 by O. Ostling and K.J. Johanson (Biochem. Biophys. Res. Commun. Vol.123: 291-298). The comet assay is a versatile and sensitive method for measuring single - and double-strand breaks in DNA. By including lesion-specific enzymes in the assay, its range and sensitivity are greatly increased, but it is important to bear in mind that their specificity is not absolute. The comet assay (with and without inclusion of lesion-specific enzymes) is widely used as a biomarker assay in human population studies - pr...
Proceedings of 9th Euro-Global Summit on Toxicology and Applied Pharmacology 2017
June 22-24, 2017 Paris, France Key Topics : Drug Toxicology, Food Toxicology, Nanotoxicology, Genetic Toxicology and Toxicity Testing, Pharmacology, Human & Health Toxicology, Toxicologic Pathology, Occupational Toxicology, Pesticide Chemistry and Toxicology, Reproductive and Developmental Toxicology, Toxicology, Pharmacology and Toxicology, Forensic Medicine and Toxicology, Toxicology of Metals, Toxicologists Meetings, Environmental Toxicology and Risk Assessment, Risk Assessment, Regulatory Toxicology, Toxicity of Consumer and Household Products, Translational Toxicology, Toxicology Databases and Informatics,
Cellular and Molecular Toxicology of Nanoparticles
This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations...
Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Nanotechnology Applications for Tissue Engineering
Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be circumvented by employing nanotechnology. It provides substrates for cell adhesion and proliferation and agents for cell growth and can be used to create nanostructures and nanoparticles to aid the engineering of different types of tissue. Written by renowned scientists from academia and industry, this book covers the recent developments, trends and innovations in the application of nanotechnologies in tissue engineering and regenerative medicine. It provides information on methodologies for designing and using bioma...
Nanocellulose and Its Composites for Water Treatment Applications
Biological materials and their applications have drawn increasing attention among scientists. Cellulose is an abundant, renewable, biodegradable, economical, thermally stable, and light material, and it has found application in pharmaceuticals, coatings, food, textiles, laminates, sensors, actuators, flexible electronics, and flexible displays. Its nano form has extraordinary surface properties, such as higher surface area than cellulose; hence, nanocellulose can be used as a substitute for cellulose. Among many other sustainable, functional nanomaterials, nanocellulose is attracting growing interest in environmental remediation technologies because of its many unique properties and function...
