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Horizons in Cancer Research. Volume 76
In Horizons in Cancer Research. Volume 76, the molecular drivers associated with prostate cancers at different stages which can be exploited as drug targets are discussed. This information will be useful for designing rational targeted therapeutic strategies for treatment of this disease.Following this, the authors discuss lung cancer early diagnosis with traditional and alternative approaches. In lung cancer, smoking exposure has been identified as the main causative agent in smokers.A critical appraisal of the different updated techniques in the mediastinal staging of lymph nodes in lung cancer is provided.The authors also provide an overview of colorectal cancer and Ca2+ signalling in cells, focusing their discussion on a specific component of the Ca2+ signalling machinery, the transient receptor potential cation channel subfamily V member 4 channel.Breast cancer, a serious public health problem, is assessed, maintaining that women need accurate and effective information in order to attain early diagnosis.Lastly, a simple technique to decreases cell-culture pH while maintaining sterile technique is described.
Horizons in Cancer Research
This book presents original research results on the leading edge of cancer. Topics discussed include the diagnosis, treatment and prevention of endometrial cancer; liver metastases of colorectal carcinoma; combination antiangiogenic therapy for patients with cancer; the aetiology and prognostic factors for lung metastases; combination therapy for controlling malignant neuroblastoma and cancer-related fatigue.
Horizons in Cancer Research. Volume 69
Horizons in Cancer Research. Volume 69 opens with a discussion on hypothetical mechanisms of the induction of NKreg cells in cancer and possible approaches to their abrogation, suggesting that for profound understanding of the problem of NKregs in the context of future target cancer immunotherapy, extensive clinical observations of NKreg cells should be carried out. Afterwards, the authors focus on the cell surface molecules in adult T-cell leukemia/lymphoma (ATL) cells, the function of matricellular proteins, particularly OPN, and their potential as targets for ATL immunotherapy. Later, the book demonstrates dual distinct functional roles of widespread cancerous immunoglobulins among cancer...
Horizons in Cancer Research
High-grade gliomas are the most frequent primitive brain malignancies of the adult and account for approximately 60-75% of all gliomas. Chapter One concludes the progress in the management of high-grade gliomas requires the simultaneous and synergic effort of a multitude of health professionals including neurosurgeons, neuroncologists, neurointerventionalists, radiologists, immunologists and neuropathologists among others. Chapter Two describes the fundamental molecular mechanisms involved in the understanding of metastatic growth, the role of some metastasis suppressor proteins in the regulation of these processes in different types of cancer, and the clinical implications of these metastas...
Horizons in Cancer Research
This book presents original results on the leading edge of cancer research. Chapter One presents an overview of the opportunities and challenges that influence the participation of personalised approach of giving the right drug at the right dose to the right patient. Chapter Two examines malignant mesothelioma. Chapter Three reviews the role of heat-shock proteins and chaperonins in the pathogenesis and progression of cancer. Chapter Four discusses the biosynthesis of LeX family glycosphingolipids and its gene regulation. Chapter Five summarises how chromosome segregation is accurately controlled and how spindle assembly checkpoint (SAC) monitors this process to maintain segregation fidelity...
Horizons in Cancer Research
This book presents original research results on the leading edge of cancer. Topics discussed include coping mechanisms in patients with head and neck cancer; hepatocellular carcinoma; chronic lymphocytic leukaemia; the pathobiology of B-lymphoproliferative disorders from MBL to CLL to SLL; molecular and cellular characterisation of chronic lymphocytic leukemia; pain as a consequence in patients with early stage breast cancer treated with intracavity brachytherapy accelerated partial breast irradiation (IBAPBI); the future of anti-tumour immunotherapy; coping with childhood cancer; and the current clinical utility of Everolimus in the treatment of renal cell carcinoma.
Horizons in Cancer Research
This book presents original results on the leading edge of cancer research. Chapter One reviews microRNAs as a novel diagnostic and predictive biomarker in human cancer. Chapter Two provides an overview of the miR-10b functions, exploring its utility as a bio-marker and a potential drug target. Chapter Three discusses the deregulated expression and function of S100 proteins in cancer cells. Chapter Four studies the current management of nasopharyngeal carcinoma and future directions in clinical research. Chapter Five examines the human papillomavirus vaccine.
