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This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel. The volume is intended for molecular biologists, biochemists and geneticists.
In order to study living organisms, scientists not only study them at an overall macroscopic scale but also on a more detailed microscopic scale. This observation, pushed to its limits, consists of investigating the very center of each cell, where we find the molecules that determine the way it functions: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). In an organism, DNA carries the genetic information, which is called the genome. It is represented as four-letter sequences using the letters A, C, G and T; based on these sequences, computer methods described in this book can answer fundamental questions in bioinformatics. This book explores how to quickly find sequences of a few hundred nucleotides within a genome that may be made up of several billion, how to compare those sequences and how to reconstruct the complete sequence of a genome. It also discusses the problems of identifying bacteria in a given environment and predicting the structure of RNA based on its sequence.
This book constitutes the refereed proceedings of the 17th Annual Symposium on Combinatorial Pattern Matching, CPM 2006, held in Barcelona, Spain in July 2006. The 33 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 88 submissions. The papers are organized in topical sections on data structures, indexing data structures, probabilistic and algebraic techniques, applications in molecular biology, string matching, data compression, and dynamic programming.
This book constitutes the refereed proceedings of the Third International Conference on Language and Automata Theory and Applications, LATA 2009, held in Tarragona, Spain, in April 2009. The 58 revised full papers presented together with 3 invited lectures and two tutorials were carefully reviewed and selected from 121 submissions. The papers address all the various issues related to automata theory and formal languages.
This book constitutes the refereed proceedings of the 10th International Conference on Rewriting Techniques and Applications, RTA-99, held in Trento, Italy in July 1999 as part of FLoC'99. The 23 revised full papers presented were carefully selected from a total of 53 submissions. Also included are four system descriptions as well as three invited contributions. Among the topics covered are constraint solving, termination, deduction and higher order rewriting, graphs, complexity, tree automata, context-sensitive rewriting, string rewriting and numeration systems, etc.
Biological evolution is the phenomenon concerning how species are born, are transformed or disappear over time. Its study relies on sophisticated methods that involve both mathematical modeling of the biological processes at play and the design of efficient algorithms to fit these models to genetic and morphological data. Models and Methods for Biological Evolution outlines the main methods to study evolution and provides a broad overview illustrating the variety of formal approaches used, notably including combinatorial optimization, stochastic models and statistical inference techniques. Some of the most relevant applications of these methods are detailed, concerning, for example, the study of migratory events of ancient human populations or the progression of epidemics. This book should thus be of interest to applied mathematicians interested in central problems in biology, and to biologists eager to get a deeper understanding of widely used techniques of evolutionary data analysis.
This book constitutes the refereed proceedings of the 9th International Conference on Rewriting Techniques and Applications, RTA-98, held in Tsukuba, Japan, in March/April 1998. The 22 revised full papers presented were carefully selected from a total of 61 submissions by the program committee with the assistance of 113 additional referees. The book covers all current aspects of rewriting including rewriting systems, term rewriting, string rewriting, theorem proving, resolution, normalization, unification, equational logics, lambda calculus, constraint solving, and functional programming.
This book constitutes the thoroughly refereed post-workshop proceedings of the 25th International Workshop on Combinatorial Algorithms, IWOCA 2014, held in Duluth, MN, USA, in October 2014. The 32 revised full papers presented were carefully reviewed and selected from a total of 69 submissions. The papers focus on topics such as Algorithms and Data Structures, Combinatorial Enumeration, Combinatorial Optimization, Complexity Theory (Structural and Computational), Computational Biology, Databases (Security, Compression and Information Retrieval), Decompositions and Combinatorial Designs, Discrete and Computational Geometry, as well as Graph Drawing and Graph Theory. IWOCA is a yearly forum for researchers in designing algorithms field to advance creativeness of intersection between mathematics and computer science. This is the first time this conference is being held in U.S.
This book constitutes the refereed proceedings of the 23rd International Symposium on the Mathematical Foundations of Computer Science, MFCS'98, held in Brno, Czech Republic, in August 1998. The 71 revised full papers presented were carefully reviewed and selected from a total of 168 submissions. Also included are 11 full invited surveys by prominent leaders in the area. The papers are organized in topical sections on problem complexity; logic, semantics, and automata; rewriting; automata and transducers; typing; concurrency, semantics, and logic; circuit complexity; programming; structural complexity; formal languages; graphs; Turing complexity and logic; binary decision diagrams, etc..