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Provides a review of novel pharmaceutical approaches for Tuberculosis drugs Presents a novel perspective on tuberculosis prevention and treatment Considers the nature of disease, immunological responses, vaccine and drug delivery, disposition and response Multidisciplinary appeal, with contributions from microbiology, immunology, molecular biology, pharmaceutics, pharmacokinetics, chemical and mechanical engineering
This new volume provides exhaustive knowledge on a wide range of natural products and holistic concepts that have provided promising in the treatment of leishmaniasis. Including the major natural therapies as well as traditional formulations, over 300 medicinal plants and 150 isolated compounds that are reported to have beneficial results in the treatment of the disease are explored in this comprehensive work. This book also acts as an important resource on various anti-inflammatory plants used to treat various inflammatory conditions of the disease.
This book is an engineering guide for design of slopes and stabilisation works in rocks and residual soils. It is tailored to the needs of practising geotechnical engineers and engineering geologists. Engineering and engineering geology students will find it quite useful and a practical course guide. It can be used as textbook in courses on landslides and slope stabilisation. The purpose of this book is to present a concise documentation on how to design slopes and how to select a slope stabilisation method. The authors are scholars and professional engineers with many years of international experience in slope stabilization works in South and Central America and the Far East.
This book is aimed at the practising engineer and engineering geologist working in tropical environments, where lands lides are mainly triggered by rain fall. This book is based on a similar work published in 1999 in Portuguese, which became the Rio de Janeiro Slope Manual. This book is an engineering guide for the design of slopes and stabilisation works in rocks and residual soils. It evolves from the cumulative experience gathered by several engineers and geologists who faced severe slope problems. The authors' experience throughout Central and South America (Costa Rica, Argentina, Bolivia, Peru, Ecuador and Venezuela) and the Far East, especially Hong Kong and Malaysia, was used as a foundation for writing this book. The work also benefits enormously from the time spent in Hong Kong in 1996 and 1997 by the first editor on sabbatical at the City University of Hong Kong, and the discussions he had with many colleagues from the Geotechnical Engineering Office (GEO) of the Hong Kong Government, especially Dr. A. Malone, Mr. w.K. Pun, Dr. A. Li, Mr. K. Ho, and Mr. y.c. Chan among others.
Various aspects, including diagnosis, therapy, and prognosis, of two brain tumors (meningioma and schwannoma) , of brain tumors are discussed in this volume. Insights on the understanding of molecular pathways involved in brain tumor biology are explained. For example, the role of E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling is discussed in detail. Such information will lead to the development of effective aniicancer drugs. The role of molecular genetics and epigenetic mechanisms in schwannomas is explained. Also, is explained the role of cyclin D1 in vestibular schwannoma. The determination of subtypes of meningiomas using perfusion ...
The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oral cholera vaccines to stop the spread of cholera outbreaks.