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Legionella Pneumophila Macrophage Infectivity Potentiator Protein Appendage Domains Modulate Protein Dynamics and Inhibitor Binding
Macrophage infectivity potentiator (MIP) proteins are widespread in human pathogens including Legionella pneumophila, the causative agent of Legionnaires' disease and protozoans such as Trypanosoma cruzi. All MIP proteins contain a FKBP (FK506 binding protein)-like prolyl-cis/trans-isomerase domain that hence presents an attractive drug target. Some MIPs such as the Legionella protein (LpMIP) have additional appendage domains of mostly unknown function. In full-length, homodimeric LpMIP, the N-terminal dimerization domain is linked to the FKBP-like domain via a long, free-standing stalk helix. Combining X-ray crystallography, NMR and EPR spectroscopy and SAXS, we elucidated the importance of...
Taking Root
Jews seeking a new life in Canada faced problems beyond those of other immigrants. Farm colonists often lived in communities too small to afford a rabbi or ritual slaughterer, or even to form a minyan for worship. In French Canada, Protestant and Catholic school boards battled over who was responsible for educating Jewish children. In the cities, the socialist philosophies of Jews fleeing the poverty and oppression of Europe were anathema to aggressive New World capitalists. And when suspicion or resentment arose, there was always someone to revive the old antisemitic slurs and myths. Taking Root is the meticulously researched record of how Canadian Jewry coped with these obstacles, and flou...
Military services and genealogical records of soldiers of Blair County, Pennsylvania
A definitive guide to veterans from Blair County, Pennsylvania who served in: Revolutionary War; War of 1812; Mexican War; Civil War; Spanish American War; and, World War 1. Many records include addresses, dates of birth and death, burial places and other information. Historical data on wars and the local area is also included.
Whittaker
None
William Blake and the Myths of Britain
William Blake and the Myths of Britain is the first full-length study of Blake's use of British mythology and history. From Atlantis to the Deists of the Napoleonic Wars, this book addresses why the eighteenth century saw a revival of interest in the legends of the British Isles and how Blake applied these in his extraordinary prophetic histories of the giant Albion, revitalising myths of the Druids and Joseph of Arimathea bringing Christ to Albion.
