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This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).
Proceedings of a NATO ASI held in Erice, Italy, April 27-May 1, 1995.
This volume is a collection of the most significant contributions to the 4th International Symposium on MULTIPLE RISK FACTORS IN CARDIOVASCULAR DISEASE: STRATEGIES OF PREVENTION OF CORONARY HEART DISEASE, CARDIAC F AlLURE, AND STROKE held in Washington, D. C. in April 1997. The meeting focused on the risk factors for cardiovascular disease and their interactions. The need for this symposium is based on the epidemiological, clinical, and biological evidence that individuals from industrialized countries often possess two or more risk factors which synergistically increase the global risk profile. This has become more evident in recent years with the increase in life expectancy of populations ...
Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.
Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s. This book covers the steps that have led to the discovery and development of these new drugs and offers detailed descriptions of their clinical applications. The review chapters on the main aspects of basic and applied leukotriene research are written by leading specialists in the field, and the volume takes a new approach in presenting information of particular interest to both scientists and clinicians in the fields of asthma, inflammation and allergic diseases.
This volume is based on the NATO Advanced Study Institute, "Advances in Mor phometries" held in 11 Ciocco, Tuscany, Italy from July 18-30, 1993, and directed by Leslie F. Marcus. The "Advances in Morphometries" ASI was advertised in Nature and a number of professional journals. Announcements were sent to relevant institutions and departments throughout the world. Because NATO required that the majority of attendees be from NATO countries, the 71 persons attending represented nine NATO countries, four eastern European countries, now recognized as equal partners for AS Is, and a few participants from non-NATO countries. Participants were all active scholars in different disciplines within biol...
This volume, the sixth in the series "The Prostaglandin System" assembles most of the lecture notes from the International School of Pharmacology on "Prostanoids and Drugs" that took place in Erice, Sicily, at the "Ettore Majorana Center for Scientific Culture" on Sept 5-15, 1989. The course, which was a NATO Advanced Study Institute, comprised detailed discussion of basic metabolic pathways of arachidonic acid as well as their location in the everyday practice of clinical medicine. The current status of our knowledge on drugs affecting prostanoid metabolic pathways, and/or their functinal effects, together with the use of prostanoids as drugs, has been reviewed in depth by distinguished exp...
Proceedings of the 11th European Society for Neurochemistry Meeting held in Groningen, The Netherlandes, June 15-20, 1996
This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.