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Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain: insights into the way the blood-brain barrier actually works (Celebrating the centenary of Goldman’s experiments)
When Ehrlich discovered the first evidence of the blood-brain barrier in 1885, he probably did not perceive the Great Wall that remained hidden from consciousness inside the central nervous system. Ehrlich had observed that acidic vital dyes did not stain the brain if they were injected into the blood stream. A century ago (1913), Goldman showed that the injection of trypan blue in the cerebrospinal fluid stained only the brain, but not the other organs. For almost a century it was thought that the blood-brain barrier (BBB) consisted in a physical barrier, resulting from the restricted permeability of the cerebral endothelial cell layer, as they are joined by tight junctions. However, as sci...
Aspects Cellulaires Et Moléculaires de la Glucuronoconjugaison
Text in English & French. Proceedings of the International Congress on Cellular & Molecular Aspects of Glucronidation held in Montpellier (France), 27-29 April 1988.
Phase II Conjugation Enzymes and Transport Systems
This volume on conjugation enzymes and transporters serves to bring together current methods and concepts in an interesting, important and rapidly developing field of cell and systems biology. Phase II Conjugation Enzymes and Transport Systems focuses on the so-called Phase II enzymes of drug metabolism (xenobiotics), which has important ramifications for endogenous metabolism and nutrition. Also included are aspects on Phase III, transport systems. This volume of Methods in Enzymology presents current knowledge and methodology on glucuronidation, sulfation, acetylation, and transport systems in this field of research. Together with the volumes on Quinones and Quinone Enzymes (volumes 378 and 382), and on Glutathione Transferases and gamma-Glutamyl Transpeptidases (volume 401), the state of knowledge on proteomics and metabolomics of many pathways of (waste) product elimination, enzyme protein induction and gene regulation and feedback control is provided. This volume will help stimulate future investigations and speed the advance of knowledge in systems biology. A laboratory standard for more than 40 years Over 400 volumes strong Also available on ScienceDirect
The Practice of Medicinal Chemistry
The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. - The only book available dealing with the practical aspects of medicinal chemistry - Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production - Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Peroxisome Proliferators
Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation, with detailed tables on the 100 known peroxisome proliferators and studies on their hepatocarcinogic capacity. It provides current material from 12 different laboratories doing cutting-edge research on the effect of peroxisome proliferators on drug-metabolizing enzymes.The book covers the response of cytochrome P450s, UDP-glucuronosyltransferases, epoxide hydrolases, glutathione S-transferase, DT-diaphorase, and other enzymes.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Endoplasmic Reticulum
The endoplasmic reticulum is a continuous membrane network in the cytosol, which encloses its internal compartment, the endoplasmic reticulum lumen. Several metabolic pathways are compartmentalised within the ER lumen, for example hydrolysis of glucose 6-phosphate, glucuronidation of endo- xenobiotics, posttranslational modification of proteins including redox reactions required for oxidative folding, oxidoreduction of steroid hormones, synthesis of ascorbate. Therefore, enzyme activities of these pathways depend on the special luminal microenvironment, on access to substrates and on release of products. However, in spite of great efforts, the molecular mechanism for the generation and maint...
Stem Cells and Regenerative Medicine
Most human tissues do not regenerate spontaneously, but the development of biotherapies using stem cells may offer promising alternatives. Among the possible medium-term therapeutic applications for this technique are: cardiac insufficiency, preparation of small diameter arteries, treatment of atherosclerosis, bone repair, cartilage defects, burns, diabetes, liver or bladder regeneration, and neurodegenerative disorders. This concept of regenerative medicine is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering, and can be seen as a way of improving health and quality of life by restoring, maintaining, or enhancing tissue and organ f...
Stem Cells and Regenerative Medicine
As the world’s population ages, the problem of degenerative disease is increasing. At the same time, the demand for organ transplants to repair or replace damaged tissue continues to grow. Regenerative medicine is a branch of translational medicine which promotes the repair, regeneration, or construction of tissues and organs or improves or restores their function through tissue engineering, cell biology, molecular biology and other techniques. Stem cells are one of the most important types of cells used in regenerative medicine, and stem cell research is also one of the most active research areas in the field. This book presents 20 full papers from the 8th International Symposium China-Eu...
