Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters
Electrical signals in living cells arise from ion channels, which cause rapid changes of the membrane potential by the selective passage of certain ions across the membrane, and transporters, which generate ion gradients on a slower time scale and thus provide the energetic basis for the passive ion flux through channels. Ion channels and transporters are expressed in almost every living cell and fulfil a plethora of distinct cellular functions. An increasing number of human diseases are caused by dysfunctional ion channels or transporters makes these proteins important targets for pharmaceutical interventions. Understanding the structural dynamics of ion channels and transporters at atomic resolution will provide new insight into their function and represents an important step towards designing blockers or activators to specifically modulate their function as therapeutic option in diseases.
Contested Will
Shakespeare scholar James Shapiro explains when and why so many people began to question whether Shakespeare wrote his plays.
Graphis
None
Stanley
Henry Morton Stanley was a cruel imperialist - a bad man of Africa. Or so we think: but as Tim Jeal brilliantly shows, the reality of Stanley's life is yet more extraordinary. Few people know of his dazzling trans-Africa journey, a heart-breaking epic of human endurance which solved virtually every one of the continent's remaining geographical puzzles. With new documentary evidence, Jeal explores the very nature of exploration and reappraises a reputation, in a way that is both moving and truly majestic.
Vineyard Chill
This thrilling addition to the Martha’s Vineyard Mystery series follows hero J.W. as he navigates threats to his family and protecting friends from his past. For year-round Vineyard residents J.W. Jackson and his wife, Zee, winter brings its own beauty, with uncrowded streets and cozy nights by the fire, but it can also bring danger. There’s a chill in the air one January day when J.W. receives a surprising visit from long-ago pal Clay Stockton. Clay has come to J.W. not to relive the reckless days of their youth but to ask J.W. for help. He’s in big trouble and needs to lie low on the Vineyard. And it isn’t just Clay who needs J.W.’s assistance; J.W.’s pal Bonzo has made a frightening discovery and becomes a “person of interest” to the police. With two friends in trouble and his own family receiving threats, J.W. must summon all of his investigative skills to try to restore order to his beloved island home, where fishing and good food should always take precedence over murder.
Purinergic Signalling in the Central Nervous System and its pharmacological importance in neurological and psychiatric illnesses.
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-sto...
De akkerbouw
None
War Elephants
Elephants have fought in human armies for more than three thousand years. This is the largely forgotten tale of the credit they deserve and the sacrifices they endured.
Beyond Bach
Reverence for J. S. Bach's music and its towering presence in our cultural memory have long affected how people hear his works. In his own time, however, Bach stood as just another figure among a number of composers, many of them more popular with the music-loving public. Eschewing the great composer style of music history, Andrew Talle takes us on a journey that looks at how ordinary people made music in Bach's Germany. Talle focuses in particular on the culture of keyboard playing as lived in public and private. As he ranges through a wealth of documents, instruments, diaries, account ledgers, and works of art, Talle brings a fascinating cast of characters to life. These individuals--amateur and professional performers, patrons, instrument builders, and listeners--inhabited a lost world, and Talle's deft expertise teases out the diverse roles music played in their lives and in their relationships with one another. At the same time, his nuanced re-creation of keyboard playing's social milieu illuminates the era's reception of Bach's immortal works.
Voltage Gated Sodium Channels
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
