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The Work of Cepezed
In the past few decades, cepezed has gained renown with transparent, sustainable and technologically progressive architecture that is remarkably usable and humane. Unaffected design, sober but stylish materialization, and careful finishing are just as characteristic of Cepezed's oeuvre as the integration of spatial and construction-technical aspects. The design and building processes at cepezed are also integrated: the use of prefab components and the application of industrial building methods guarantee an optimum alignment of design and realization, in which time, quality, and costs are meticulously planned and controlled. Prototypes documents a large number of key projects and deals extens...
Principles of Immunopharmacology
This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.
Reducing Animal Use in Carcinogenicity Testing
Carcinogenicity to rats and mice is evaluated for substances to which humans are exposed, including pharmaceuticals, agrochemicals, and industrial chemicals. For pharmaceuticals, recent efforts to reduce animal use in long-term studies include an addendum to the International Council for Harmonisation (ICH) guideline S1B(R1) that prioritizes short-term studies in transgenic mice and recommends assessing the weight of evidence available to first determine whether a long-term study in rats would add value. For other sectors, an expert group of the Organisation for Economic Cooperation and Development (OECD) is developing an Integrated Approach to the Testing and Assessment (IATA) of non-genotoxic carcinogens based on common hallmarks of cancers and on key characteristics of carcinogens. Within current regulations, animal use could be reduced by evaluating toxicokinetics in main study animals with microsampling methods, by including only one negative control group, and by genotyping transgenic mice instead of using positive control groups in each study.
Nonclinical Safety Assessment
Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a p...
To My Dear Pieternelletje
To my dear Pieternelletje describes a ten-year period in the lives of Pieternella van Hoorn and her grandfather Willem van Outhoorn, former governor-general of the Dutch East Indies. Eleven years old, Pieternella left for Amsterdam and the only contact possible was by mail. Numerous letters have survived and combined with contemporaneous documents, most of them never published before, they offer a vivid and clear picture of their private life and feelings, forming a most welcome addition to official VOC-history. Van Outhoorn not only acted as Pieternella’s mentor while she tried to adjust to her new but unknown fatherland, but also sent her numerous exquisite presents, the greater part of which has been traced and described in full, thus offering new insight in the cultural history of Asia.
Principles of Immunopharmacology
The rapid developments in immunology in recent immunomodulatory drugs can be distinguished years have dramatically expanded our knowledge of from their beneficial therapeutic effects. mammalian host defence mechanisms. The molecu- Currently,it is only possible to obtain an overview lar mechanisms of cellular interactions during of these various aspects of immunopharmacology immune responses have been unravelled,the intra- by reading a range of immunological,pharmacol- cellular responses involved in signal transduction ical,diagnostic and toxicological literature. Good delineated and an ever-increasing number of soluble immunological textbooks are available, while mediators of immune and infl...
Doing Business 2009
The Doing Business series provides research, data, and analysis on regulation in 181 economies across 10 areas of the business life cycle. Doing Business 2009 identifies top reformers in business regulation and highlights best practices and global reform trends. This year s report builds upon the five previous editions, adding new economies and updating all indicators. This year s report covers 3 additional economies, bringing the total number of economies covered to 181. Now included are the Bahamas, Bahrain, and Qatar. The report also adds a preface on Doing Business methodology, as well as in-depth analysis throughout the report on the main trends and findings of the past six years of Doi...
RDA: Resource Description and Access: 2013 Revision
This e-book contains the 2013 Revision of RDA: Resource Description and Access, and includes the July 2013 Update. This e-book offers links within the RDA text and the capability of running rudimentary searches of RDA, but please note that this e-book does not have the full range of content or functionality provided by the subscription product RDA Toolkit. Included: - A full accumulation of RDA-- the revision contains a full set of all current RDA instructions. It replaces the previous version of RDA Print as opposed to being an update packet to that version. RDA has gone through many changes since it was first published in 2010. Cataloging practice described by RDA has not changed dramatica...
Doing Business 2014
Eleventh in a series of annual reports comparing business regulations in 189 economies, Doing Business 2014 measures regulations affecting 11 areas of everyday business activity around the world.
