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Handbook of Proteolytic Enzymes
Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing f...
DNA and Histone Methylation as Cancer Targets
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
Histone Recognition
This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.
Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms
This book is an introduction to epigenetics, a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Starting with the discovery of repressor proteins in the 1960s, epigenetics evolved into a kind of user manual for the genetic information, telling the genome if, when, how much and in what cells to read genes. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences and an understanding of its basic principles is therefore essential for every student in this field.The field of chromatin and epigenetics has developed ...
Solid State Ionics
Solid atate ionics, being a multidisciplinary area, is expected to grow at a faster rate in the new millennium, prompting the discovery of new materials and devices, as well as helping to optimize the known devices, especially the portable power sources and display systems. The Asian Society for Solid State Ionics (ASSSI) plays a significant role in bringing together researchers from the Asian countries, every two years, to exchange notes and ideas, to foster friendship and collaboration, and to discuss the prospects. The topics covered in this volume are: ion dynamics, theoretical modeling, ion-conducting polymers, gels and ceramics, glasses, crystalline materials including nano-phases, com...
DNA Methyltransferases - Role and Function
This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.
Solid State Ionics: Materials & Devices, Procs Of The 7th Asian Conf
Solid state ionics, being a multidisciplinary area, is expected to grow at a faster rate in the new millennium, prompting the discovery of new materials and devices, as well as helping to optimize the known devices, especially the portable power sources and display systems. The Asian Society for Solid State Ionics (ASSSI) plays a significant role in bringing together researchers from the Asian countries, every two years, to exchange notes and ideas, to foster friendship and collaboration, and to discuss the prospects.The topics covered in this volume are: ion dynamics, theoretical modeling, ion-conducting polymers, gels and ceramics, glasses, crystalline materials including nano-phases, comp...
Reform Of The International Monetary System And Internationalization Of The Renminbi
This book argues that only by reforming the international monetary system can we prevent financial crises in the future and the internationalization of the Renminbi, China's national currency, will be an important step in the process.Just as the old saying goes, 'An old building needs to be demolished before a new one can be erected in its place,' there will be no construction without destruction. The commencement of the dismantling of the old monetary system is also the beginning of the construction of the new one. Contrary to Western rhetoric, which portrays China as part of the cause of the recent financial crisis, the author contends that China is actually a victim of the current unjust ...
Globalization and State Transformation in China
As China develops its economy, the author argues it will be held back by its refusal to import democratic values.
