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Computer Simulations of Protein Structures and Interactions
Protein engineering endeavors to design new peptides and proteins or to change the structural and/or functional characteristics of existing ones for specific purposes, opening the way for the development of new drugs. This work develops in a comprehensive way the theoretical formulation for the methods used in computer-assisted modeling and predictions, starting from the basic concepts and proceeding to the more sophisticated methods, such as Monte Carlo and molecular dynamics. An evaluation of the approximations inherent to the simulations will allow the reader to obtain a perspective of the possible deficiencies and difficulties and approach the task with realistic expectations. Examples from the authors laboratories, as well as from the literature provide useful information.
Transmembrane Dynamics of Lipids
The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes. Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asym...
Parker's Wine Buyer's Guide
Parker's acclaimed guide, fully revised with ratings on the latest vintages from around the world, is one of the most authoritative wine guides available and now comes with expanded sections on the popular wines of California and Italy.
Parker's Wine Buyer's Guide, 7th Edition
Featuring a fresh layout, revised maps, and more detail than ever before, the seventh edition of Parker's Wine Buyer's Guide offers collectors and amateurs alike the ultimate resource to the world's best wines. Understanding that buyers on every level appreciate a good deal, Parker separates overvalued bottles from undervalued, with wine prices instantly shifting according to his evaluations. Indifferent to the wine's pedigree, Parker's eminent 100-point rating system allows for independent, consumer-oriented, inside information. The latest edition of Parker's Wine Buyer's Guide includes expanded information on Spain, Portugal, Germany, Australia, Argentina, and Chile, as well as new sections on Israel and Central Europe. As in his previous editions, Parker provides the reassurance of a simple number rating, predictions for future buying potential, and practical overviews of regions and grapes. Altogether, an indispensable resource from the man the Los Angeles Times calls “the most powerful critic of any kind.”
Robert Parker
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High-Performance Liquid Chromatography of Peptides and Proteins
This book consists of a series of 82 precise, easy-to-read articles by internationally renowned scientists and emphasizes the practical approach to HPLC with minimal theory, although the underlying principles for peptide and protein separations are clearly expressed. All of the major modes of microbore, ultrafast and analytical HPLC are discussed, including size-exclusion, ion-exchange, reversed-phase, hydrophobic interaction, and affinity and immunoaffinity chromatography. A section on preparative HPLC, including displacement techniques, is also presented. Problem-solving approaches to the separation of various classes of biologically active peptides and proteins are thoroughly explored, wh...
Parker's Wine Bargains
Yes, you can buy world-class wine on a budget. With Parker's Wine Bargains, America's most infl uential wine critic offers a guide to the world's best wines priced at $25 or less. Robert M. Parker, Jr., earned his international reputation and unprecedented influence as a dedicated consumer advocate -- if a wine isn't worth the money, he says so, regardless of the wine's pedigree. In Parker's Wine Bargains, for the first time he and his Wine Advocate team offer budget-minded wine buyers a handy guide to low-priced wines for both everyday drinking and special occasions. Organized by country, the book lists more than 1,500 quality wine producers, as well as abbreviated tasting notes for more than 3,000 of the best value wines. Chapters include an overview of each country's wine-producing regions, highlight up-and-coming or underappreciated regions, and detail when wines can be consumed. Also featuring a vintage guide and lists such as "the best of the best," Parker's Wine Bargains is an accessible guide from the expert the New York Times deems "the critic who matters most."
