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Small Volume Bone Marrow Aspirates with High Progenitor Cell Concentrations Maximize Cell Therapy Dose Manufacture and Substantially Reduce Donor Hemoglobin Loss
Abstract: Background Bone marrow (BM) transplantation is a life-saving therapy for hematological diseases, and the BM harbors also highly useful (progenitor) cell types for novel cell therapies manufacture. Yet, the BM collection technique is not standardized. Methods Benchmarking our collection efficiency to BM collections worldwide (N = 1248), we noted a great variability of total nucleated cell (TNC) yields in BM products (HPC-M) with superior performance of our center, where we have implemented a small volume aspirate policy. Thus, we next prospectively aimed to assess the impact of BM collection technique on HPC-M quality. For each BM collection (N = 20 donors), small volume (3 mL) and ...
Wissenschaftliches Arbeiten in der Pflege
Das erfolgreiche Lehrbuch hat sich innerhalb kürzester Zeit als Standardwerk etabliert. Es fasst alle relevanten Informationen über wissenschaftliches Arbeiten für Pflegende kurz und konkret zusammen. Verständlich wird erklärt, was wissenschaftliches Arbeiten in der Pflege bedeutet, mit welchen Techniken gearbeitet wird und welche Produkte als Ergebnis wissenschaftlichen Arbeitens entstehen.Neben einer Einführung in wissenschaftliches Arbeiten beschreiben die AutorInnen konkret, wie man kritisch denkt, englische Texte liest und schreibt, gut zuhört, effektiv mitschreibt, klug fragt, klar argumentiert, gewinnend referiert, auf den Punkt zusammenfasst, anschaulich visualisiert, effektiv...
Cancer Research
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Computational Pharmaceutics
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein bi...
Applications of Geodesy to Engineering
Accuracy requirements of fractions of a millimeter for the positioning of beam-guiding magnets in synchrotons, monitor- ing of speedy sub-seatunnelling with lengths exceeding 25 km, the construction of extremely long bridges of suspension or "cast-and push"-type, but also geometrical industrial quality control and robot calibration in real time, and even the analysis of prestressed cable nets, are few examples of thechallenging new tasks demanding responses from the modern engineering-geodesist. In this volume, a general view of Engineering Geologyis presented, its state of the art and up-to-date information about recent scientific tasks, aims and methods. The contributions focus on Theoreti...
