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Integration of Omics Approaches and Systems Biology for Clinical Applications
Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape o...
Mammals and Birds as Bioindicators of Trace Element Contaminations in Terrestrial Environments
The population explosion that began in the 1960s has been accompanied by a decrease in the quality of the natural environment, e.g. pollution of the air, water and soil with essential and toxic trace elements. Numerous poisonings of people and animals with highly toxic anthropogenic Hg and Cd in the 20th century prompted the creation of the abiotic environment, mainly in developed countries. However, the system is insufficient for long-term exposure to low concentrations of various substances that are mainly ingested through food and water. This problem could be addressed by the monitoring of sentinels – organisms that accumulate trace elements and as such reflect the rate and degree of environmental pollution. Usually these are long-lived vertebrates – herbivorous, omnivorous and carnivorous birds and mammals, especially game species. This book describes the responses of the sentinels most commonly used in ecotoxicological studies to 17 trace elements.
A Crying Shame
For ten-year-old Christine, home is a hostile place. Then, on a family holiday in Scotland, something terrible happens and, panic-stricken, Christine and her brother run away and hide in the back of a stranger's car. And a troubled little girl becomes a lonely spinster's salvation.
The People and the State
This volume is the fourth in the series Corollaria Crustumina and deals with the results of the project The People and the State, Material culture, social structure, and political centralisation in Central Italy (800-450 BC). This project of the Groningen Institute of Archaeology, carried out between 2010 and 2015 in close collaboration with the Archaeological Service of Rome, deals with the changing socio-political situation at ancient Crustumerium resulting from Rome's rise to power. The volume brings together data from the domains of geology, geoarchaeology, urban and rural settlement archaeology, funerary archaeology, material culture studies as well as osteological and isotope analyses. On the basis of these data, a relationship is established between changes in material culture on the one hand and developments in social structure and political centralisation in Central Italy on the other in the period between 850 and 450 BC.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Who's who of Southern Africa
Vols. for 1967-70 include as a section: Who's who of Rhodesia, Mauritius, Central and East Africa.
A Heart of Stone
In the words of bestselling author Susan Vreeland, “Renate Dorrestein knows how to chill her readers with tragedy and then melt their hearts with forgiveness.” A Heart of Stone is a story of love, fate, and survival that plumbs the undercurrents of family life with passion and skin-prickling suspense. Growing up with her adored siblings in a rambling house in Holland, clever, precocious Ellen has an idyllic childhood suffused with Americana from her parents’ news-clipping service—from Coca-Cola to Kissinger to Neil Armstrong’s first step on the moon. But amid the happiness lies terror and unimaginable heartbreak and a twelfth birthday that haunts her still. Twenty-five years later, as Ellen tries to make sense of her adulthood, she brilliantly captures her loss and longings and her struggles to dispel the ghosts of her past. “A stunning novel about the scorching legacy of loss.”—Time “A striking and finely tuned novel.”-The New York Times
Modern Alkaloids
This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis. A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.
Percy’s Bus
Using a century of journals written by Susan Briars' father, Percy, and grandfather, Ernest Taylor, this book chronicles the everyday lives of her extraordinary, extended family, as told from her father’s viewpoint, covering the war years and observing the changing society.
