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Pertussis Infection and Vaccines
This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines. Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vacci...
Updating Long COVID: Mechanisms, Risk Factors, and Treatment
The SARS-CoV-2 virus has led to the worldwide outbreak of the twentieth century. Current knowledge on SARS-CoV-2 acute infection has dramatically increased. Three years after the main outbreak, the presence of long-lasting symptoms after the acute infection called long COVID or post-COVID-19 syndrome, affects millions of individuals worldwide. Increasing literature supports the presence of more than 100 potential symptoms after the acute phase of infection such as: · extreme fatigue, dizziness, and insomnia · depression and anxiety, memory and concentration impairments · loss of smell or taste, tinnitus, and earaches · chest pain, heart palpitations, tightness, muscle aches. However, several gaps still are present in the identification, timeframe, mechanisms, and treatment strategies for the management of long-COVID.
Mitochondrial Cyclophilin D is a Critical Regulator of T Cell Mediated Immunity to Mycobacterium Tuberculosis
"Despite the world-wide application of BCG vaccination and other anti-Mycobacterium tuberculosis (Mtb) interventions, Mtb remains one of the most pervasive human pathogens. The ability of Mtb to persist in individuals with apparently normal immune systems implies that Mtb has developed strategies to evade and even subvert innate and adaptive immunity. The high success of this pathogen is closely linked to its ability to alter the intracellular environment of the alveolar macrophages (M[phi]). Mtb eventually induces necrosis, a type of cell death that favors Mtb survival and progression of disease. Interestingly, virulent Mtb actively inhibit apoptosis, an alternate form of M[phi] death, whic...
Perseverance Drive
Against the rising Bajan sun, the Gillard family gathers to lay their mother Grace to rest. Eli, devout follower of the Church of God of Providence and father to three, reluctantly welcomes his wayward son, Josh, back into the fold. London, five years later. The table is set for another family reunion. Tiger Malt for the men, Juiceys for the women and lashings of Madeira cake are washed down with a familiar dose of holy water. But past shadows illuminate old passions and these fragile relationships are tested for the last time. From the vibrant colours of Barbados to the grey skies of Leytonstone, this bittersweet play follows one family’s struggle to reconcile their faith in God with faith in one another.
Longitudinal Clinical Phenotyping of Post COVID Condition in Mexican Adults Recovering from Severe COVID-19: a Prospective Cohort Study
Abstract: Introduction: Few studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexican patients with PCC. Methods: We prospectively enrolled and followed adult patients hospitalized for severe COVID-19 at a tertiary care centre in Mexico City. The incidence of PCC symptoms was determined using questionnaires. Unsupervised clustering of PCC symptom co-occurrence and Kaplan-Meier analyses of symptom persistence were performed. The effect of baseline clinical characteris...
Sessional Papers
"Report of the Dominion fishery commission on the fisheries of the province of Ontario, 1893", issued as vol. 26, no. 7, supplement.
Julia Gillard
None
Joint Volumes of Papers Presented to the Legislative Council and Legislative Assembly
Includes various departmental reports and reports of commissions. Cf. Gregory. Serial publications of foreign governments, 1815-1931.
