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TRAF Proteins in Human Disease
Tumor necrosis factor receptor (TNFR) associated factors (TRAFs) are a family of signaling adaptors first identified as components of TNFR signaling complexes, but now recognized to regulate signal transduction downstream of a diverse array of receptors, including Toll like receptors, antigen receptors and cytokine receptors. TRAF proteins play important roles in many human diseases and processes as both positive and negative regulators. This eBook begins with a review of TRAF structure, followed by reviews on the role of TRAFs in NF-kB and mitogen activated protein kinase (MAPK) signaling as well as in signaling downstream of innate pattern recognition receptors. Next is a review focused on...
Annual Report
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Chronic Lymphocytic Leukemia
B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.
Bulletin
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Suitability of portable NIR sensors (food-scanners) for the determination of fruit quality along the supply chain using the example of tomatoes (Band 50)
Food-scanners are novel, portable and miniaturized devices, which operate on the principle of near-infrared spectroscopy (NIRS). According to the manufacturers, these devices are suitable for measuring a wide range of important quality parameters on fresh produce. This research evaluated the suitability of food-scanners for determining fruit quality along the supply chain of fruit and vegetables. Using the qualitative research approach, the first step of this research comprised interviews of experts at different positions along the fresh produce value chain in Germany. Thereby, preferences and concerns regarding the utilization and implementation of this technology for fresh produce were inv...
Apoptosis
This text is designed to provide conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptosis. Chapters on the recognition of apoptosis as distinguished from necrosis and nonspecific cell DNA damage, are followed by a systematic examination of the established and the principal novel methodologies utilized by some leading laboratories conducting research on apoptosis. The organization is on the lines of signalling for apoptosis, the apoptotic cascade, and the execution of apoptosis. A wide variety of procedures are provided which will enable the reader to participate in cutting-edge research.
Registro oficial
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