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Chronic Lymphocytic Leukemia
B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.
TRAF Proteins in Human Disease
Tumor necrosis factor receptor (TNFR) associated factors (TRAFs) are a family of signaling adaptors first identified as components of TNFR signaling complexes, but now recognized to regulate signal transduction downstream of a diverse array of receptors, including Toll like receptors, antigen receptors and cytokine receptors. TRAF proteins play important roles in many human diseases and processes as both positive and negative regulators. This eBook begins with a review of TRAF structure, followed by reviews on the role of TRAFs in NF-kB and mitogen activated protein kinase (MAPK) signaling as well as in signaling downstream of innate pattern recognition receptors. Next is a review focused on...
Chronic Lymphocytic Leukemia
"Chronic lymphocytic leukemia (CLL) formerly was considered an incurable 'old man's disease" caused by slowly accumulating, incompetent lymphocytes. This volume summarizes many of the recent advances that have shaped a new way of thinking about this disease."
Cuban Fusion
None
Short-Term Occupations in Paleolithic Archaeology
This edited book aims to provide a new perspective on the identification and interpretation of short-term occupations in Paleolithic Archaeology. The volume includes contributions with a particular focus on the definition and identification of short-term occupations in Paleolithic contexts, aiming to improve our current knowledge on the topic, both methodologically and interpretatively. The set of chapters coming from a broad spectrum of geographies and chronologies will contribute to the debate on the definition of short-term occupations but also to a better understanding on how past hunter-gatherers communities adapted and moved in different environmental contexts across time. The in-depth examinations of short-term occupations in different chronologies and environments will shed light on an aspect of the behavioral trajectories of the human species in the management of the territory.
Mexican Political Biographies, 1935-2009
"Teresa Lozano Long Institute of Latin American Studies."
2007
Die International Bibliographiy of Historical Sciences verzeichnet jährlich die bedeutendsten Neuerscheinungen geschichtswissenschaftlicher Monographien und Zeitschriftenartikel weltweit, die inhaltlich von der Vor- und Frühgeschichte bis zur jüngsten Vergangenheit reichen. Sie ist damit die derzeit einzige laufende Bibliographie dieser Art, die thematisch, zeitlich und geographisch ein derart breites Spektrum abdeckt. Innerhalb der systematischen Gliederung nach Zeitalter, Region oder historischer Disziplin sind die Werke nach Autorennamen oder charakteristischem Titelhauptwort aufgelistet.
Neanderthal Lifeways, Subsistence and Technology
The 150th anniversary of the discovery of the famous Neanderthal fossils gave reason for an international and interdisciplinary symposium in Bonn/Germany. The present book arose from this congress and focuses on multiple aspects of archaeological investigation on Neanderthal lifeways. In-depth studies of top-ranking scientists provide a detailed and comprehensive survey of contemporary research on our Pleistocene relatives. Examinations and debates are embedded in a variety of regions and time frames. Chronology, subsistence, land use, and cultural adaptations among late Neanderthals form the major trajectories of the book. The wide range of approaches involved, leads to an increasing understanding of the facets of and the variability of Neanderthal behavioural patterns. The present volume is complemented by a paleontologically orientated publication of the same congress (edited by Gerd-Christian Weniger and Silvana Condemi).
