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Chronic Lymphocytic Leukemia
B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.
Hematology
Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of blood diseases. This has in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options in hematology requires a frequent update of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research in hematological diseases with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients, as well as on some molecular and pathogenetic mechanisms and the respective translation into novel therapies.
Recombinant protein expression in microbial systems
With the advent of recombinant DNA technology, expressing heterologous proteins in microorganisms rapidly became the method of choice for their production at laboratory and industrial scale. Bacteria, yeasts and other hosts can be grown to high biomass levels efficiently and inexpensively. Obtaining high yields of recombinant proteins from this material was only feasible thanks to constant research on microbial genetics and physiology that led to novel strains, plasmids and cultivation strategies. Despite the spectacular expansion of the field, there is still much room for progress. Improving the levels of expression and the solubility of a recombinant protein can be quite challenging. Accum...
Hematologia
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Art from Your Core
This book guides artists through the discovery and development of the art that they alone were born to create. Through real-life examples and exercises, we tear down the cultural, educational, and psychological obstacles to finding authentic visual voice, stripping away years of assumptions, external and self-imposed limiting parameters. We learn how to listen to the Universe and get out of the way when work wants to come through us. We construct a core foundation, unique to each artist, one that will grow along with them in their artistic practice. Artists will discover their own singular visual vocabulary by mining their personal history, psyche, and world view to reveal new creative direc...
Insoluble Proteins
With insolubility proving to be one of the most crippling bottlenecks in the protein production and purification process, this volume serves to aid researchers working in the recombinant protein production field by describing a wide number of protocols and examples. Insoluble Proteins: Methods and Protocols includes chapters that describe not only the recombinant protein production in different expression systems but also different purification and characterization methods to finally obtain these difficult-to-obtain proteins. Beginning with protein production methods using both prokaryotic and eukaryotic expression systems, the book continues with purification protocols using insoluble prote...
Ambient Intelligence – Software and Applications
This book includes the outcomes of the 11th International Symposium on Ambient Intelligence (ISAmI 2020). The 11th International Symposium on Ambient Intelligence is hosted by the University of L’Aquila and is going to be held in L’Aquila (Italy). Initially planned on the 17th to the 19th of June 2020, it was postponed to the 7th to the 9th of October 2020, due to the COVID-19 outbreak.
Jungian Psychology and the Human Sciences
This volume brings together selected papers from the 2021 IAJS conference focusing on Jungian psychology’s place within the broader human science field, with contributions providing an interdisciplinary examination of fields such as psychoanalysis, feminism, critical thought, and eco-psychology. The historical foundations of Jungian thought in phenomenology, hermeneutics, the significance of imagination, and the body’s genetics open the book with outstanding essays from both renowned and aspiring new scholars. Chapters highlighting matters of current social, political, and ecological considerations shed light on the intersections between Jungian psychology and much contemporary thought i...
