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Immunologic tumor microenvironment modulators for turning ”cold“ tumors to ”hot“ tumors
Cancer immunotherapy is based on using the immune system components to fight tumors, without destroying normal cells. Several immunotherapeutic strategies have been investigated and proposed for the treatment of cancers, including cancer vaccines containing tumor antigens that are used to induce immune responses against tumors, monoclonal antibodies against tumor antigens, and immune checkpoint inhibitors. However, many clinical trials have shown that the use of these methods as monotherapy is ineffective in many cases. Many tumors can resist immunotherapy due to the absence or insufficient infiltration of tumors with CD8+ T cells and hence, are called “cold” or non-inflammatory tumors. ...
FM4 Wortlaut 19. Privat
FM4 bietet Nachwuchsautor*innen und allen, die Lust am Geschichtenschreiben haben, die Chance, sich in kurzer Form literarisch über das Thema "PRIVAT" auszulassen. Die redaktionelle Vorjury wählt aus den cirka 1.000 Einreichungen 20 aus, die an die hochkarätige Jury weitergegeben werden. Diese kürt dann die Gewinner*innen, die zehn besten Texte schaffen es in die Anthologie Wortlaut 19. Es lauschen aufmerksam in die Privatsphäre: Marc Elsberg (Autor), Diana Köhle (Slamveranstalterin und -moderatorin), Verena Rossbacher (Autorin), Mercedes Spannagel (Wortlautgewinnerin 2018) und Daniel Wisser (Musiker und Autor). Mit Texten von: Katherina Braschel, Sophia Fritz, Lukas Gmeiner, Anita Hetzenauer, Martin Peichl, Florian Schlederer, Anna Schwingenschuh, Julia Steinbichler, Johanna Wohlgemuth und Andrea Zipko. Mit einem Vorwort von Verena Rossbacher.
'Heimat'
The concept of Heimat with its seemingly pre- or anti-modern connotations of rootedness in a place of origin is central to a critical understanding of German history and culture. Over the course of the past fifteen years, scholars across a range of disciplines have found new ways to examine the changing notions of Heimat – its multifaceted cultural, literary, and visual history, its gendered connotations, and its national and ideological appropriations. This anthology is the first to examine cultural manifestations of Heimat by giving special consideration to issues of memory and space. The contributions to this volume challenge static notions of place often associated with Heimat. Instead...
The Digital Transformation of Product Formulation
In competitive manufacturing industries, organizations embrace product development as a continuous investment strategy since both market share and profit margin stand to benefit. Formulating new or improved products has traditionally involved lengthy and expensive experimentation in laboratory or pilot plant settings. However, recent advancements in areas from data acquisition to analytics are synergizing to transform workflows and increase the pace of research and innovation. The Digital Transformation of Product Formulation offers practical guidance on how to implement data-driven, accelerated product development through concepts, challenges, and applications. In this book, you will read a...
Clinical Pancreatology for Practising Gastroenterologists and Surgeons
Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for t...
Kein schöner Land
Der deutschsprachige Heimatfilm, mit den großen Anfangserfolgen Schwarzwaldmädel (1950), Grün ist die Heide (1951) und Der Förster vom Silberwald (1954), steht für eine beispiellose Unterhaltungsfilmwelle, die über ein Jahrzehnt Spitzenwerte bei Besucherzahlen und Verleihumsätzen erzielte. Bis heute finden die volkstümlichen Unterhaltungen ein Stammpublikum auf den Fernsehbildschirmen. Die Geschichte des Heimatfilms, sowie der weiteren Filme, die sich der Bestandteile des Genre bedienten, ist auch ein Spiegelbild des Landes. "Kein schöner Land" erzählt die Geschichte des deutschen Film-Genre in unserer einzigartigen Landschaft, lässt die Dreharbeiten vieler Produktionen aufleben, stellt die Stars und Macher des Genres vor, und soll eine Lücke in der Aufarbeitung der deutschen Filmgeschichte schließen und eine unentbehrliche Lektüre für die vielen Freunde des deutschen Heimatfilms werden.
Proceedings of the European Computing Conference
The European Computing Conference offers a unique forum for establishing new collaborations within present or upcoming research projects, exchanging useful ideas, presenting recent research results, participating in discussions and establishing new academic collaborations, linking university with the industry. Engineers and Scientists working on various areas of Systems Theory, Applied Mathematics, Simulation, Numerical and Computational Methods and Parallel Computing present the latest findings, advances, and current trends on a wide range of topics. This proceedings volume will be of interest to students, researchers, and practicing engineers.
