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Human Genetic Diversity
The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Contemporary genetic research is allowing the basis of both rare inherited disorders and common multifactorial diseases like asthma and diabetes to be more clearly defined. Huge investments are being made and great advances have been achieved, bu...
Genomic Medicine
The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.
Genomics and Clinical Medicine
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Julian Grenfell
A biography of the First World War poet Julian Grenfell. It helps readers to understand why Julian and his generation seemed to want to die in battle. It also brings Edwardian society to life, as well as describes his relationship with his mother.
Medieval Women's Writing
Medieval Women's Writing is a major new contribution to our understanding of women's writing in England, 1100-1500. The most comprehensive account to date, it includes writings in Latin and French as well as English, and works for as well as by women. Marie de France, Clemence of Barking, Julian of Norwich, Margery Kempe, and the Paston women are discussed alongside the Old English lives of women saints, The Life of Christina of Markyate, the St Albans Psalter, and the legends of women saints by Osbern Bokenham. Medieval Women's Writing addresses these key questions: Who were the first women authors in the English canon? What do we mean by women's writing in the Middle Ages? What do we mean ...
Gene Mapping, Discovery, and Expression
Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific...
They Knew Mr. Knight
A Book Society Choice, shortlisted for the Femina-Vie Heureuse Prize, the second Dorothy Whipple novel we publish is also wonderfully well-written in a clear and straightforward style; yet 'this real treat' ("Sunday Telegraph") is far more subtle than it at first appears. The Blakes are an ordinary family: Celia looks after the house and Thomas works at the family engineering business in Leicester. The book begins when he meets Mr Knight, a financier as crooked as any on the front pages of our newspapers nowadays; and tracks his and his family's swift climb and fall.Part of the cause of the ensuing tragedy is Celia's innocence - blinkered by domesticity, she and her children are the 'victim of the turbulence of the outside world' (Postscript); but finally, through 'quiet tenacity and the refusal to let go of certain precious things, goodness does win out' (Afterword). And the "TLS" wrote: 'The portraits in the book are fired by Mrs Whipple's article of faith - the supreme importance of people.'
The Informal Media Economy
How are “grey market” imports changing media industries? What is the role of piracy in developing new markets for movies and TV shows? How do jailbroken iPhones drive innovation? The Informal Media Economy provides a vivid, original, and genuinely transnational account of contemporary media, by showing how the interactions between formal and informal media systems are a feature of all nations – rich and poor, large and small. Shifting the focus away from the formal businesses and public enterprises that have long occupied media researchers, this book charts a parallel world of cultural intermediaries driving global media production and circulation. It shows how unlicensed, untaxed, or unregulated networks, which operate across the boundaries of established media markets, have been a driving force of media industry transformation. The book opens up new insights on a range of topical issues in media studies, from the creative disruptions of digitisation to amateur production, piracy and cybercrime.
