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Biological Monitoring
At the invitation of the Deutsche Forschungsgemeinschaft (DFG), a round-table discussion was held on 9 and 10 March 2000, dealing with future possibilities for biomonitoring in occupational and environmental medicine. Biomonitoring has reached a high standard in Germany over the past 30 years, not least due to the fact that the results of the Senate commission on materials hazardous to health at the workplace have been directly implemented as part of the jurisdiction relating to occupational safety. This book combines the expertise gathered from various areas within toxicology, occupational medicine, immunology and human genetics, right up to analysis and epidemiology. Throughout, the focus ...
Essential Biomonitoring Methods
For more than 30 of the most important occupational toxicants, detailed, ready-to-use protocols for human biomonitoring methods are provided. All methods are reliable, reproducible, in accordance with 'Good Laboratory Practice' standards and cover all required steps from sampling to the interpretation of results. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors. The documented methods are authoritative, because they were compiled by the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. The Commission is internationally acknowledged for its neutrality and is working strictly according to transparent, scientific criteria.
Analyses of Hazardous Substances in Biological Materials
The 8th volume of Analyses of Hazardous Substances in Biological Materials contains 10 analytical methods to determine chemical substances and their metabolites in human body fluids. These methods principally serve to monitor compliance with the Biological Tolerance Values (BAT values) assigned by the Commission. Due to their high sensitivity they are suitable for checking reference values and human biomonitoring values (HBM values) that are established by the "Human Biomonitoring" Commission of the Umweltbundesamt [German Ministry for the Environment].
Analyses of Hazardous Substances in Biological Materials
Since exposure to hazardous substances, commonplace in the modern industrial environment, can lead to adverse effects on health, statutory limits are established for the levels of such substances in the workplace air and of the substances themselves or their metabolites in the body fluids of workers. Therefore reliable analytical methods are required to determine the levels of such substances in air and in body fluids (usually blood or urine). The Analytical Chemistry Group of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has established new methods and standardized old ones for the biological monitoring of numerous industrial chemicals. The analytical reliability and reproducibility of each of the methods has been determined by the author and confirmed by at least one examiner. The methods are therefore suitable for checking adherence to statutory limits such as the German BAT values (Biological Tolerance Values for Working Materials) and the American BEI values (Biological Exposure Indices) and for reliable detection of dangerous substances in the tissues of individual workers.
Analysis of Hazardous Substances in Biological Materials
Biological monitoring has proved extremely valuable in assessing the health risk of persons exposed to hazardous chemical substances in the environment or at the workplace. The chemical compounds are generally determined in body fluids. They are present in trace or ultratrace concentrations. Specific and extremely sensitive methods of chemical analysis are necessary to separate these substances from the biological matrix and to determine them precisely. This volume contains 12 standardized analytical methods. All methods are suitable for routine use. They meet exceptionally high standards of reliability and reproducibility and are in accordance with 'Good Laboratory Practice'. Considerable emphasis is placed on sample collection methods and on analytical quality control.
Analyses of Hazardous Substances in Biological Materials
The 8th volume of Analyses of Hazardous Substances in Biological Materials contains 10 analytical methods to determine chemical substances and their metabolites in human body fluids. These methods principally serve to monitor compliance with the Biological Tolerance Values (BAT values) assigned by the Commission. Due to their high sensitivity they are suitable for checking reference values and human biomonitoring values (HBM values) that are established by the "Human Biomonitoring" Commission of the Umweltbundesamt [German Ministry for the Environment].
Analyses of Hazardous Substances in Biological Materials
The 9th volume of the series contains 11 validated and tested analytical methods and a collection of 6 LightCycler assissted real time methods with which the genotype and phenotype of a person can be determined with regard to the polymorphism of certain enzymes. The methods and enzymes selected here represent the current state fo the art in this field. These analytical methods are accompanied by chapters avout the biochemical basis of the susceptibility markers and by recommendations from the DFG Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area on how physicians should evaluate the analytical results.
Analyses of Hazardous Substances in Biological Materials
The 9th volume of the series contains 11 validated and tested analytical methods and a collection of 6 LightCycler assissted real time methods with which the genotype and phenotype of a person can be determined with regard to the polymorphism of certain enzymes. The methods and enzymes selected here represent the current state fo the art in this field. These analytical methods are accompanied by chapters avout the biochemical basis of the susceptibility markers and by recommendations from the DFG Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area on how physicians should evaluate the analytical results.
Analysis of Hazardous Substances in Biological Materials
Biological monitoring has proved extremely valuable in assessing the health risk of persons exposed to hazardous chemical substances in the environment or at the workplace. The chemical compounds are generally determined in body fluids. They are present in trace or ultratrace concentrations. Specific and extremely sensitive methods of chemical analysis are necessary to separate these substances from the biological matrix and to determine them precisely. All methods are suitable for routine use. They meet exceptionally high standards of reliability and reproducibility and are in accordance with 'Good Laboratory Practice'. Considerable emphasis is placed on sample collection methods and on analytical quality control.
Analyses of Hazardous Substances in Biological Materials
Since exposure to hazardous substances, commonplace in the modern industrial environment, can lead to adverse effects on health, statutory limits are established for the levels of such substances in the workplace air and of the substances themselves or their metabolites in the body fluids of workers. Therefore reliable analytical methods are required to determine the levels of such substances in air and in body fluids (usually blood or urine). The Analytical Chemistry Group of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has established new methods and standardized old ones for the biological monitoring of numerous industrial chemicals. The analytical reliability and reproducibility of each of the methods has been determined by the author and confirmed by at least one examiner. The methods are therefore suitable for checking adherence to statutory limits such as the German BAT values (Biological Tolerance Values for Working Materials) and the American BEI values (Biological Exposure Indices) and for reliable detection of dangerous substances in the tissues of individual workers.
