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This book is a printed edition of the Special Issue "Nutritional Intake and the Risk for Non-alcoholic Fatty Liver Disease (NAFLD)" that was published in Nutrients
Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the c...
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features:...
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
In this issue, guest editors bring their considerable expertise to this important topic. - Contains 20 practice-oriented topics, including metabolic syndrome associated with NASH; genetic markers and comorbidities predisposing to NASH and progressive liver disease; the role of bariatric surgery and endobariatric surgery in NASH; future treatment options and regimens for NAFLD; and more. - Provides in-depth clinical reviews on non-alcoholic steatohepatitis, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Krankheiten der Verdauungsorgane sind Volkskrankheiten. Jährlich werden mehr als 2,5 Millionen Patienten mit Krankheiten der Verdauungsorgane im Krankenhaus behandelt. 61.000 Menschen sterben daran. Bis 2030 ist mit einer weiteren Zunahme um mehr als 20 % zu rechnen. Doch schon heute existieren durch die gastroenterologische Forschung wirksame Präventionsmaßnahmen gegen Krankheiten von Leber, Magen, Darm oder Speiseröhre und werden fortlaufend weiterentwickelt. Prävention ist entscheidend, wenn es darum geht, gastroenterologische Krankheiten aber auch Folgekrankheiten an anderen Organen zu vermeiden oder aufzuhalten. Um für die Zukunft zu erreichen, dass kein Mensch mehr an Krebs der V...