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Chemical and Structural Approaches to Rational Drug Design
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
Manual of Immunological Methods
The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to
Endothelin Receptors
Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
Introduction to Neurobehavioral Toxicology
Introduction to Neurobehavioral Toxicology: Food and Environment examines the effects of chemicals on the central and peripheral nervous system and the subsequent changes in behavior, with a focus on the toxicity of food components and behavioral effects of environmental toxicants. Topics addressed include acute and chronic effects; reversible and
Angiotensin II Receptors
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors. This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
Genomic and Non-Genomic Effects of Aldosterone
This exciting new book summarizes the known features of both the more traditional genomic aldosterone effects and those modern aspects of non-genomic aldosterone effects discovered within the past few years. International specialists contribute to the scholarship on these issues. Chapters include discussions on traditional genomic mineralocorticoid physiology; mineralocorticoid receptor theory; and rapid non-genomic steroid effects in the brain, kidneys, smooth muscle cells, and lymphocytes.
Treatment of Dementias
Alzheimer's disease is one the foremost health problems facing every society fortunate enough to attain a level of medical care that ensures an average lifespan of over 70 years of age. The cause of the disease remains unknown, and no single therapeutic approach has yet been found highly efficacious. Indeed, as the complexity of its effects on brain neuronal systems becomes elucidated, the concept emerges that Alzheimer's disease may be an umbrella term for multiple Alzheimer's-type syndromes that can be differentiated based on etiology (hereditary versus sporadic), neurochemical deficits, and extent of pathology. Whether one or more disease processes is involved, it seems increasingly unlik...
Infectious Diseases in Immunocompromised Hosts
Because of limited access to medical libraries and medical journals, the majority of clinicians may find it difficult to keep informed on the latest developments in drug manufacture and treatment of infectious diseases in immunocompromised patients. This new handbook strives to fulfill the need for information in this area of medicine. This is the first book on drug development and treatment of infectious diseases in immunocompromised hosts. It integrates both results from large-scale clinical trials and single cases as well as small groups of patients. It covers bacterial, viral, parasitic, and fungal infections, including a wide array of diseases. Infectious Diseases in Immunocompromised Hosts encompasses not only opportunistic infections associated exclusively with immunocompromised patients, but also common infections that become life-threatening for immunosuppressed individuals.
