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Current Catalog
First multi-year cumulation covers six years: 1965-70.
Basic and Clinical Aspects of Growth Hormone
In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena. Because many more people can be treated with available growth hormone, clinicians must be prepared to answer hard questions regarding appropriate therapeutic usage and their decisions should be based on substantiated research in growth hormone. In June 1987, an international group of basic and clinical inves tigators gathered in Tampa, Florida, to address these issues and to further explore the very nature of growth hormone. The presentations contained within this book bring together their most current and vital research related ...
Insulin-like Growth Factor Receptor Signalling
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Basic and Clinical Approach to Turner Syndrome
A lot of progress has been made in the field of genetics, pathophysiology and treatment of patients with Turner syndrome over the past couple of years. The International Symposium on Turner Syndrome was organized with a view to bringing together researchers throughout the world to facilitate exchange of their knowledge and most recent findings. In total, 45 papers were presented, covering genetics, natural history, endocrine function, bone metabolism, psychosocial problems, growth factors and various kinds of treatment. This publication should serve as a useful guide for Turner patients, researchers and physicians.
Subject Catalog
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Advances in Metabolic Disorders
Advances in Metabolic Disorders, Volume 8: Somatomedins and Some Other Growth Factors covers the proceedings of the 28th Nobel Symposium held at Hasselby, Sweden on September 4-7, 1974. The book discusses the mechanisms regulating cellular growth; the purification procedures and biological properties of nonsuppressible insulin-like activity (NSILA-S); and physiologic and pharmacologic significance of NSILA-S as an insulin-like hormone and as a growth-promoting hormone. The text also describes the in vitro effects of growth hormone on cyclic AMP metabolism in the isolated rat diaphragm; the interaction of epidermal growth factor with cultured fibroblasts; and the localization, purification, m...
