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Extradigestive Manifestations of Helicobacter Pylori Infection
Helicobacter pylori is an ancient microorganism that co-evolved with humans for many years and typically colonizes the human stomach and is being recognized as the most common infectious pathogen of the gastroduodenal tract. Some years after bacterium isolation, epidemiological studies have revealed a correlation between its infection and some diseases localized outside the stomach, such as hematological, hepatobiliary, pancreatic, cardiovascular, neurological, dermatological and respiratory diseases. Different mechanisms of action have been proposed, ranging from the induction of a low-grade inflammatory state to the occurrence of molecular mimicry mechanisms. This book is an overview of contributors surrounding the association of H. pylori infection with extragastric diseases, based on evidence, bacterial-host interactions and mechanisms implicated in the pathogenesis of some of these disorders.
Free Radical Biology in Digestive Diseases
There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and p...
Holistic Cancer Medicine
*As Seen on Chris Beat Cancer A groundbreaking, comprehensive guide on managing, treating, and preventing cancer. *Introducing: The Holistic Model of the Twelve Vital Fields* It’s a sad truth of our times that one in three people will experience cancer in their lifetime. By 2040, the probability will rise to one in two. As a comprehensive guide on natural treatment, Holistic Cancer Medicine is essential reading for every cancer patient—from newly diagnosed to late stage. For those seeking to prevent the disease, it also provides key information on how to reduce your risks. As the founder and director of Germany’s leading complementary cancer clinic, Dr. Henning Saupe offers Holistic Ca...
Multi-Targeted Approach to Treatment of Cancer
In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by multi-faceted approaches that target these underpinnings. This book emphasizes a multi-targeted approach to treating cancer, the focus of the 5th International Conference on Translational Cancer Research that was held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.
Oxidative Stress, Inflammation, and Health
Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-an
Genetics Abstracts
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Signal Transduction Pathways, Part D
Keynote speakers at the cell signaling meeting in Luxembourg have provided chapters on hypoxia signal transduction, phosphoserine/threonine-binding domains, targeting of polycomb repressive complexes, conserved signaling mechanisms in innate immunity, and signal transduction by stress-activated MAP kinases. Other topics included among these reports on recent research are receptor signaling, protein kinase cascades as therapeutic targets, cell death in cancer, inflammation-specific signaling, cell signaling pathways leading to regulated chromatin modifications, and transcriptional control. The chapters have been published in four volumes (Part A to D), offering a comprehensive overview about ...
