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Interaction between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer
The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat wi...
Hyaluronan
Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering.The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers:Analytical chemistryStructural elucidation and basic chemistryElectron microscopy and atomic force microscopyProduction, purification and characterisationQuality in production systemsChemical mo...
Hyaluronan
This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug del...
Extracellular Vesicles
Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.
AACR 2016: Abstracts 2697-5293
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
Extracellular Vesicles as Matrix Messengers
The cells in our body release a wide variety of factors into the extracellular space that help to signal, regulate and build the extracellular matrix. One of the most fascinating of these factors are extracellular vesicles (EVs). These lipid membrane-covered particles have now emerged as a new powerful method of near and distant intercellular communication. EVs facilitate communication between cells and their extracellular environment, which includes solid tissues and body fluids. This volume summarizes current knowledge on EVs as integral and active components of the extracellular matrix. It covers topics such as the interplay between EVs and ECM molecules and how cancer cells modify their ...
Hyaluronan Signaling and Turnover
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students
