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Between the Lines of Genetic Code
Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environme...
Between the Lines of Genetic Code
Functional analysis of genetic variants in association with human complex diseases remains a challenge for modern research. Discovery of gene–gene interactions may represent an additional tool for identifying specific polymorphisms involved in disease development. It not only identifies new candidate genes for mechanistic studies, but also suggests biological relations in the function of these genes with certain variants in developing disease. We describe a few examples of the studies where a link between statistical evidence of gene–gene interaction was found with the expression or function of genes of interest. Finally, we present future perspectives for integration genetic epidemiology data with biologically relevant mechanisms of disease.
Myocarditis
This book is an up-to-date, comprehensive, clinically oriented guide to the diagnosis and treatment of patients with myocarditis. The opening chapters address the classification, histopathology and molecular diagnosis, as well as the polymorphic clinical presentations, ranging from myocardial infarction with normal coronary arteries; arrhythmias of variable type and clinical severity and fulminant, acute, sub-acute or chronic heart failure; to life-threatening unexplained cardiogenic shock and sudden cardiac death. Including chapters from leading International experts in the field, it covers all key issues from bench to bedside. Topics presented include epidemiology, etiology, pathogenesis, ...
The Common Thread
John Sulston was director of the Sanger Centre in Cambridge from 1993 to 2000. There he led the British arm of the international team selected to map the entire human DNA sequence, a feat that was pulled off in record time by an extraordinary collaboration of scientists. Despite innumerable setbacks and challenges from outside competitors the ultimate success of the project can be attributed in large part to John Sulston's own determination, passion and scientific excellence. In this personal account he takes us behind the scenes of one of the largest international scientific operations ever undertaken. He is frank about the competition with Craig Venter and Celera Genomics, which threatened...
Types of Alcoholics
This volume, containing 16 papers, explores recent research and current theory pertaining to alcoholic typologies, giving special emphasis to genetic suscepibility and biological markers of clinical subtypes. This treatment is timely in view of recent trends in genetic epidemiology, treatment matching, and biological markers for alcoholism. The papers present recent research findings, explore commonalities across diverse theoretical and methodological approaches, and consider implications for diagnosis and treatment.
The Common Good and Christian Ethics
The Common Good and Christian Ethics rethinks the ancient tradition of the common good in a way that addresses contemporary social divisions, both urban and global. David Hollenbach draws on social analysis, moral philosophy, and theological ethics to chart new directions in both urban life and global society. He argues that the division between the middle class and the poor in major cities and the challenges of globalisation require a new commitment to the common good and that both believers and secular people must move towards new forms of solidarity.
God, Ethics and the Human Genome
Advances in genetic science and medicine raise questions for us all, such as: How far should we intervene in 'natural' processes? How far should we go to alleviate suffering? What constitutes a worthwhile life? Exploring these questions and more, this book considers theological, ethical and legal aspects relating to the human genome.
The Other Book Addiction
Challenges the current paradigm regarding addiction as a chronically relapsing brain disease. Creates a more plausible paradigm encompassing early dysregulating trauma created by Adverse Childhood Experiences, ACE's which are precursors to the development of mental disorders which lead to the need for self medication with psychoactive substances. Challenges the lack of choice in human behavior and cites the more recent data supporting conceptualization as a thinking disorder.
