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The ventricular-subventricular zone: a source of oligodendrocytes in the adult brain
Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that reside within a niche denominated ventricular-subventricular zone (V-SVZ) in the lateral wall of the cerebral ventricles. NSCs give rise to neurons and oligodendrocytes that help preserve cellular homeostasis. Growing evidence indicates that V-SVZ progenitor cells may represent an endogenous source of oligodendrocytes that can be useful to treat demyelinating diseases. This e-Book “The v...
Novel insights in rehabilitation of neglect, 2nd Edition
Hemispatial neglect is the failure to report, respond to, or orient to novel or meaningful stimuli presented in the contralesional visual field. It constitutes one of the most invalidating neurological disorders that can occur after stroke. It is therefore important to treat neglect as adequate as possible and much of the research dedicated to neglect therefore focuses on rehabilitation. In this special topic, you will find 29 articles on the rehabilitation of neglect. This Research Topic has opened new perspectives, and has given us an indication of where the field is going. Although some of the current rehabilitation techniques have proven to be beneficial, there is limited agreement on the most valuable technique or the mechanisms underlying the ameliorating effects.
Spatial and Non-Spatial Aspects of Neglect
Neglect is one of the most impressive neuropsychological disorder, for both its theoretical and clinical relevance. Besides being very common and disabling, it is highly informative for understanding normal cognitive functioning. The hallmark of neglect is the failure to attend to the contralesional hemispace. However, several studies have recently highlighted that additional deficits, not attributable to a spatial bias, are associated to the impaired contralesional hemispace processing. Moreover, manifestations of neglect tend to be particularly heterogeneous and often dissociate according to the spatial domain being investigated (e.g., body space, space within reaching, space beyond reachi...
Neuropsychology and Neuropsychiatry of Neurodegenerative Disorders
This book compiles all articles within the Research Topic "Neuropsychology and neuropsychiatry of neurodegenerative disorders" published in the journal Frontiers in Aging Neuroscience. The call was launched in 2014 and closed in 2015 with 21 articles published. Papers deal on several important topics of neuropsychology -such as language and visuospatial functions- and neuropsychiatry - such us the emotional or motivational spheres - , and the interphase between them. There are also articles on psychometry, brain morphometry, brain connectivity, diagnostic tests and interventional studies. All these articles are focused on neurodegenerative conditions, mostly Alzheimer’s disease and Parkinson’s disease. Interestingly, several articles addressed the early stages of these diseases. All together, this Research Topic provides a rich perspective of the research made today around neuropsychological and neuropsychiatric aspects of neurodegenerative diseases. We hope readers enjoy this collection of articles.
Advances in Cognitive Neuroscience of Numerical and Mathematical Processing
In this special issue, the most recent advances in the domain of numerical cognition will be presented. During the last decades, our understanding of how numbers are processed increased dramatically with the arrival of different imaging techniques and neurophysiological experiments in humans and monkeys. We are now starting to build up a clearer picture of how numbers are represented in the brain, how this representation develops in the course of a lifetime, how numbers are embedded in other cognitive features like attention, spatial memory, etc., and how this eventually leads to our capability to perform complex mathematics. Ultimately, this accumulation of knowledge might provide us with a...
ERS Handbook of Paediatric Respiratory Medicine
The 19 sections of this second edition of the ERS Handbook of Paediatric Respiratory Medicine cover the whole spectrum of paediatric respiratory medicine, from anatomy and development to disease, rehabilitation and treatment. The editors have brought together leading clinicians to produce a thorough and easy-to-read reference tool. The Handbook is structured to accompany the paediatric HERMES syllabus, making it an essential resource for anyone interested in this field and an ideal educational training guide.
Difficult and Severe Asthma in Children
Globally, severe asthma is defined by the WHO as either (A) untreated severe asthma; (B) difficult-to-treat severe asthma; and (C) treatment-resistant severe asthma. Untreated severe asthma is a political problem: the children do not have access to the basic tools for asthma management, and when this is corrected, asthma outcomes are transformed. The problem in difficult-to-treat severe asthma is not the airway disease, but co-morbidities and behavioral factors. This is the group in which there are most asthma deaths, underscoring that severe asthma cannot be solely defined by levels of prescribed therapy. Treatment-resistant severe asthma is rare and challenging, and the problem is the airway pathology. These children require new and innovative therapies.
From Deep Learning to Rational Machines
"This book provides a framework for thinking about foundational philosophical questions surrounding machine learning as an approach to artificial intelligence. Specifically, it links recent breakthroughs in deep learning to classical empiricist philosophy of mind. In recent assessments of deep learning's current capabilities and future potential, prominent scientists have cited historical figures from the perennial philosophical debate between nativism and empiricism, which primarily concerns the origins of abstract knowledge. These empiricists were generally faculty psychologists; that is, they argued that the active engagement of general psychological faculties-such as perception, memory, ...
Tutorials in Visual Cognition
In the late-1980s, visual cognition was a small subfield of cognitive psychology, and the standard texts mainly discussed just iconic memory in their sections on visual cognition. In the subsequent two decades, and especially very recently, many remarkable new aspects of the processing of brief visual stimuli have been discovered -- change blindness, repetition blindness, the attentional blink, newly-discovered properties of visual short-term memory and of the face recognition system, the influence of reentrant processing on visual perception, and the surprisingly intimate relationships between eyeblinks and visual cognition. This volume provides up-to-date tutorial reviews of these many new developments in the study of visual cognition written by the leaders in the discipline, providing an incisive and comprehensive survey of research in this dynamic field.
