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Liver Myofibroblasts
Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.
Regional Change in Industrializing Asia
First published in 1998 this boo responds to the dynamics of Industrializing Asia and the behavioural changes of actors which, in response to changing internal and external forces, have given rise to and are constantly giving rise to alterations in patterns of growth. From a geographical perspective, these are expressed in regional change, understood as a reconstruction of spatial organization. The imperatives of dynamic comparative advantage, changing global or regional competitiveness, and regional competition, faced by different actors, entities or territorial units can be identified as important forces underlying and shaping regional change. This volume provides further illumination, con...
The Global Crisis in Foreign Aid
The internal destabilization of many poor countries that accompanied the end of the Cold War and the general failure of structural adjustment programs have changed the nature and allotment of foreign aid around the world. Major donors of foreign aid such as the United States, Japan, and the European Union have been shifting their geographical priorities in allocating aid, as well as their project emphasis, since the end of the Cold War. In addition, multilateral aid agencies—the World Bank, the United Nations, and the International Monetary Fund—are attempting to redress past failures of aid and revamp policies and priorities. Moreover, aid recipients in Africa, the Middle East, Asia, ...
Industrial Transition
Recently, the international division of labour in industrial production has grown increasingly more volatile. The separation between 'high-end' tasks undertaken in the traditional core economies and 'low-end' tasks undertaken in newly emerging economies has become increasingly blurred. The new dynamics and unpredictability of actor and process configurations in internationalized production bring new challenges for research in economic geography, regional economics and management sciences. The allocation of R&D and production mandates within or between enterprises, the setting up, closing down, purchase or sale of subsidiaries at different localities, the shifting patterns of collaborative in...
