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Blood Banking and Transfusion Medicine
Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belo...
The Antibodies
This book responds to dramatic current developments in molecular and cellular biology, and in the increasingly interrelated disciplines of genetics, immunology/immunotherapy and microbiology. Advances in molecular biology, genetic engineering, cloning and DNA sequencing have made it possible to model, design, and produce specific-purpose antibody molecules. This ability to alter molecular/protein structures, and even create new ''tailor-made'' molecules and proteins, is a quantum leap for both basic science and clinical medicine. The Antibodies: Volume 1 shows the applications of engineered antibodies in diagnosis immunotherapy, and protein purification, and provides new insights into the structural basis of antigen binding, effector functions, and regulation of the immune response. These therapeutic and practical uses of antibody engineering are possible by focusing on established as well as emergent concepts, methods, and techniques.
Molecular Biology of B-Cell and T-Cell Development
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cell...
Antibodies
Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them, their properties and structural characteristics is still incomplete. The Antibodies: Volume 2 is a comprehensive review of topics of contemporary interest for specialists in B cell immunology. This volume investigates such topics as sequencing the variable regions of human antibodies directed against exogenous antigens; a review of the protective immune response; a review of the utilization of the VH4-34 (VH4-21) gene segment in normal, neoplastic and autoimmune repertoires; and a review of antigenized antibodies. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Oxford Textbook of Medicine
The Oxford Textbook of Medicine provides all that any doctor needs to know to practice top-level internal medicine. It gives compreensive coverage of the epidemiology, aetiology, and mechanism of disease, as well as clear, unambiguous coverage of the diagnosis, practical management and prevention of the entire spectrum of medical disorders. There are major introductory sections on the scientific basis of disease; and in the system-based clinical sections genetic predisposition, pathophysiology, pathogenesis, molecular mechanisms, and cell biology are covered in depth for all significant medical syndromes. Clinical descriptions of diseases are clearly and memorably written, based on the exper...
Immunobiology of Proteins and Peptides VII
The articles in this volume represent papers delivered by invited speakers at the 7th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss their significance in the light of current concepts and to identify i...
Nathan and Oski's Hematology of Infancy and Childhood
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full ra...
Nathan and Oski's Hematology of Infancy and Childhood E-Book
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you’ll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski’s Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the ful...
Alloimmunity
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Recent Advances in Cytometry
Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. This new edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay. Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays * Discusses many new assays developed since the previous edition. Presents recent developments in cytometric intrumentation/technology.
