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Genomic Prediction of Complex Traits
This volume explores the conceptual framework and the practical issues related to genomic prediction of complex traits in human medicine and in animal and plant breeding. The book is organized into five parts. Part One reminds molecular genetics approaches intending to predict phenotypic variations. Part Two presents the principles of genomic prediction of complex traits, and reviews factors that affect its reliability. Part Three describes genomic prediction methods, including machine-learning approaches, accounting for different degree of biological complexity, and reviews the associated computer-packages. Part Four reports on emerging trends such as phenomic prediction and incorporation i...
Transgenerational Epigenetics
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thorou...
Art
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Zoological Record
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Gauge Theory of Weak Decays
"The ultimate question of elementary particle physics is: What is the fundamental Lagrangian of nature surrounding us? The Lagrangian of the SM is very successful in describing nature at the currently available energy range. The discovery of the Higgs boson completed the particle spectrum of the SM and it is another proof of how well the SM works. Nevertheless the SM cannot be the end of the story and it is for sure not the fundamental Lagrangian of nature. The Lagrangian of the SM looses its validity at the latest at the Planck scale where gravitational effects become noticeable.Most physicists think of the SM as an effective theory that has to be replaced by a more fundamental theory above the TeV scale. What the word effective really means will hopefully be clear at later stages of our book. For the time being we will list some problems and open questions of the SM"--
Transgenerational Epigenetics
Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.
植物生理学报
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