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Cancer Immunology and Immunotherapy
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Bellewether
"I've loved every one of Susanna's books! She has bedrock research and a butterfly's delicate touch with characters—a sure recipe for historical fiction that sucks you in and won't let go!"—DIANA GABALDON, #1 New York Times bestselling author of Outlander From New York Times & USA Today bestselling author Susanna Kearsley—A magical novel that blends history, forbidden romance and the paranormal Secrets aren't such easy things to keep: It's late summer in 1759, war is raging, and families are torn apart by divided loyalties and deadly secrets. In this complex and dangerous time, a young French-Canadian lieutenant is captured and billeted with a Long Island family, an unwilling and unwel...
Linux in a Nutshell
Over the last few years, Linux has grown both as an operating system and a tool for personal and business use. Simultaneously becoming more user friendly and more powerful as a back-end system, Linux has achieved new plateaus: the newer filesystems have solidified, new commands and tools have appeared and become standard, and the desktop--including new desktop environments--have proved to be viable, stable, and readily accessible to even those who don't consider themselves computer gurus. Whether you're using Linux for personal software projects, for a small office or home office (often termed the SOHO environment), to provide services to a small group of colleagues, or to administer a site ...
Early Livermore
Englishman Robert Livermore jumped ship in Southern California in 1822, yet just 15 years later became the respected owner of the 40,000-acre Las Positas land grant. Here he built his new Californio wife an adobe house in 1839. The wealth that flowed into California during the gold rush allowed Livermore to import a two-story house around the Horn, but entrepreneurs and squatters flowed in as well. Nathaniel Patterson opened the first hotel in the old Livermore adobe, frequented by miners on their way from the South Bay to the Sierra gold mines. Laddsville, a village built where the roads to Stockton and Dublin met, was also a going concern until the Central Pacific pushed over the Altamont Pass. On this line grew the town founded by William Mendenhall in 1869, named for pioneer Livermore, who had died more than a decade earlier. Soon Livermore became the valley's commercial center for hay, wheat, barley, wine grapes, and ranching.
Haploidentical Transplantation
In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.
Miscanthus for Energy and Fibre
Most land in the United States is in rural areas, as are the sources of most of its fresh water and almost all its other natural resources. One of the first books to approach resource economics and rural studies as fundamentally interconnected areas of st
