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Molecular Nanomachines of the Presynaptic Terminal
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.
Gene Therapy for the Central and Peripheral Nervous System
Gene therapy is at the forefront of current techniques that aim to re-establish functional connectivity, after an insult to the brain, spinal cord or peripheral nerves. Gene therapy makes the most of the existing cellular machinery and anatomical networks to facilitate molecular changes in DNA, RNA and proteins aiming to repair these disrupted connections. For instance, gene therapy is currently being used to target genes in conditions including spinal cord injury, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke and multiple sclerosis, amongst others. The various delivery routes include viral-vectors, genetically modified cellular implants, naked DNA/RNA, liposomes, Cre-Lox re...
Molecular Chaperones and Neurodegeneration
Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
Neuroscience Letters
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Methods for Synaptic Interrogation
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Angel Disfrazado
LUCIA: Bella, carismtica y soadora, confa sus sentimientos, alegras y temores a un viejo cuaderno buscando tal vez, ser comprendida y apreciada por aquel, quien un da la valor como a una perla preciosa y al otro, la descuid por encerrarse en el mundo de sus negocios. El destino no le fue favorable; el mar de la vida, despoj de la concha a esta perla preciosa y la arrastr hacia el abismo de un acantilado profundo y oscuro, la muerte, de la que no pudo escapar. Luca, tiene la vida de cualquier mujer comn y corriente; en su niez, la felicidad de tener una familia unida; en su juventud, los dilemas propios de la edad y en su edad media, los desafos a los que tiene que enfrentarse para mantener un equilibrio emocional. Desafortunadamente para ella, una energa negativa no se le apartaba y le obstaculizaba el paso hacia la felicidad total. Solo el amor verdadero podra sacarla del limbo al que haba sido condenada.
