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Architecture of the Heme-translocating CcmABCD/E Complex Required for Cytochrome C Maturation
Abstract: Mono- and multiheme cytochromes c are post-translationally matured by the covalent attachment of heme. For this, Escherichia coli employs the most complex type of maturation machineries, the Ccm-system (for cytochrome c maturation). It consists of two membrane protein complexes, one of which shuttles heme across the membrane to a mobile chaperone that then delivers the cofactor to the second complex, an apoprotein:heme lyase, for covalent attachment. Here we report cryo-electron microscopic structures of the heme translocation complex CcmABCD from E. coli, alone and bound to the heme chaperone CcmE. CcmABCD forms a heterooctameric complex centered around the ABC transporter CcmAB that does not by itself transport heme. Our data suggest that the complex flops a heme group from the inner to the outer leaflet at its CcmBC interfaces, driven by ATP hydrolysis at CcmA. A conserved heme-handling motif (WxWD) at the periplasmic side of CcmC rotates the heme by 90° for covalent attachment to the heme chaperone CcmE that we find interacting exclusively with the CcmB subunit
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Handbook Industry 4.0
The handbook presents an overview of Industry 4.0 and offers solutions for important practical questions. The law and its current challenges regarding data assignment (who owns the data? / EU guidelines), data security, data protection (General Data Protection Regulation), cyberattacks, competition law (right to access vs. monopolists, permissible and prohibited exchanges of information, possible collaborations) is the point of departure. In turn, the book explores peculiarities in specific areas of Industry 4.0 (Internet of Production, mechanical engineering, artificial intelligence, electromobility, autonomous driving, traffic, medical science, construction, energy industry, etc.). The book’s closing section addresses general developments in management, the digital transformation of companies and the world of work, and ethical questions.
Sustainable Energy Consumption in Residential Buildings
As the residential buildings sector accounts for around 30 percent of the final energy demand in Germany, this sector is increasingly becoming the focus of public attention with regard to climate change. In this book, decisions on energy consumption by private households are examined. The analyses are based on several empirical methods. The results show that the road to more sustainable energy consumption in residential buildings is not hampered by a lack of will on behalf of the consumers. However one should be realistic that there are many instances where improving thermal institution involves additional economic costs for individual households.
Spatial Impacts of Climate Change
Climate change has been a central concern over recent years, with visible and highly publicized consequences such as melting Arctic ice and mountain glaciers, rising sea levels, and the submersion of low-lying coastal areas during mid-latitude and tropical cyclones. This book presents a review of the spatial impacts of contemporary climate change, with a focus on a systematic, multi-scalar approach. Beyond the facts – rises in temperature, changes in the spatial distribution of precipitation, melting of the marine and terrestrial cryosphere, changes in hydrological regimes at high and medium latitudes, etc. – it also analyzes the geopolitical consequences in the Arctic and Central Asia, changes to Mediterranean culture and to viticulture on a global scale, as well as impacts on the distribution of life, for example, in the Amazon rainforest, in large biomes on a global scale, and for birds.
Forschung an humanen embryonalen Stammzellen
Die Forschung mit embryonalen Stammzellen gehört in Deutschland seit Jahren zu den in der Öffentlichkeit besonders kontrovers diskutierten Fragen. Aus ethischer, rechtlicher und sozialwissenschaftlicher Perspektive wirft die Verwendung von humanen embryonalen Stammzellen und induzierten pluripotenten Stammzellen in der Grundlagenforschung, der sich abzeichnenden klinischen Anwendung oder auch der ebenfalls näher rückenden Nutzung von Stammzellen als Testsystemen eine Reihe von Fragen auf, die, neben eher allgemeinen Fragen der Ethik der Stammzellforschung, den Fokus der Beiträge des vorliegenden Sammelbandes bilden.
Transformative Ethik - Wege zum Leben
Steht uns eine moralische Revolution bevor? Wir leben in einer Zeit der Polarisierung. Ethische Konflikte nehmen zu - in unserer Gesellschaft ebenso wie in Kirchen und Gemeinden. Was sind die Kriterien für gute und moralische Entscheidungen? In diesem Buch geht es speziell um Veränderungen im Bereich der Ethik. Es hilft Leserinnen und Lesern, moralische Konflikt durch biblische Leitlinien selbstständig zu lösen. Ethik zum Selberdenken. Band 2.1 der Reihe "Interdisziplinäre Studien zur Transformation" (IST) Zur Reihe: Immer häufiger begegnet es uns - das Thema Transformation: Die Bundesregierung hat eine große Studie zu Transformation und Umwelt beauftragt, Christen diskutieren in Vort...
