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Bald nach Erscheinen des Bandes "Geschwülste" "Geschwiilste" 1956 1956 wurde wurde deutlich, deutlich, daß daB dies dies nur ein Anfang gewesen sein konnte. Die grundlegenden Beitrage Beiträge dieses Bandes spiegelten den Wissensstand am Beginn des 6. Jahrzehnts wider. Sie waren wahrscheinlich zugleich die letzten echten Handbuchbeitrage Handbuchbeiträge zu diesem Thema: umfassend und enzyklopadisch enzyklopädisch vollständig vollstandig und trotzdem als Ganzes lesbar, verfaßt verfaBt von den damals besten Sachkennern in Deutschland. Inzwischen hat sich das Handbuch der Allgemeinen Pathologie gewandelt. Entsprechend der Weitung des Faches vergrößerten vergroBerten sich die Themen. N...
The First International Congress on DNA Damage and Repair was held in Rome, Italy, July 12-17, 1987. It was organized by the Italian Com mission for Nuclear Alternative Energy Sources. The subject of DNA damage and repair involves almost all the fields ofbidogical sciences. Some of the more prominent ones include carcino genesis, photobiology, radiation biology, aging, enzymology, genetics, and molecular biology. These individual fields have their own interna tional meetings and although the meetings often have sessions devoted to DNA repair, they do not bring together a wide diversity of international workers in the field to exchange ideas. The purpose of the Congress was to facilitate such...
Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, April 29-May 2, 1985
From the Reviews of Previous Volumes "In perusing these chapters, I found much of interest. It is worth investigating." -P. BRICKNELL "Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are ocncerned with the living cell." BRITISH MEDICAL JOURNAL Key Features * Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology * Contributions from leaders in their fields * Abundant references
Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer".
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exp...
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