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Intrinsically Disordered Proteins
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Cellular Lipid Metabolism
For years lipids have fascinated cell biologists and biochemists due to their profound effects on cell function. "Cellular Lipid Metabolism" highlights new concepts and recent findings, but also reviews important discoveries made in the past. Outstanding international experts contribute 13 chapters on the genetics, molecular and cell biology of lipids. Presenting analyses at the molecular level they reveal the principles by which cellular lipid metabolism functions. Further, numerous intriguing observations that cannot yet be explained are identified, stimulating the readers to future studies. This book provides an invaluable source of information for biomedical researchers in energy metabolism, vascular biology, endocrinology and lipidology.
The Guide to Investigation of Mouse Pregnancy
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pre...
Inhibitors of Protein Kinases and Protein Phosphates
The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles.
Knobil and Neill's Physiology of Reproduction
The 3rd edition, the first new one in ten years, includes coverage of molecular levels of detail arising from the last decade's explosion of information at this level of organismic organization. There are 5 new Associate Editors and about 2/3 of the chapters have new authors. Chapters prepared by return authors are extensively revised. Several new chapters have been added on the topic of pregnancy, reflecting the vigorous investigation of this topic during the last decade.The information covered includes both human and experimental animals; basic principels are sought, and information at the organismic and molecular levels are presented. *The leading comprehensive work on the physiology of reproduction*Edited and authored by the world's leading scientists in the field*Is a synthesis of the molecular, cellular, and organismic levels of organization*Bibliogrpahics of chapters are extensive and cover all the relevant literature
Nuclear Receptors in Development
A superb compilation of reviews from leading experts in the field of nuclear receptors, volume 16 in the Advances in Developmental Biology series covers the role of different nuclear receptor subfamilies in development, physiology and metabolism. This volume brilliantly reviews how genetic defects in the function of nuclear receptors leads to various developmental defects. Receptors discussed include: thyroid receptors, peroxisome proliferators activated receptors, and retinoic acid receptors. Additionaly, this volume offers an indespesable chapter on the orphan receptors Ftz-F1, COUPs, and RORs in embryonic and postnatal development. * Provides a compilation of reviews of several nuclear receptor subfamilies - such as TRs, PPARs, RARs, the orphan receptors COUP-TFs, RORs, and Ftz-F1 in embryonic and postnatal development. * Offers a detailed section on retinoid receptor signaling * Covers the role of co-repressors and co-activators in modulation of nuclear receptor functions
Structure, Function and Regulation of TOR complexes from Yeasts to Mammals
This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Viva and OSCE Exams in Ophthalmology
This book provides a core revision resource for candidates sitting part 2 of the FRCOphth and other UK and international qualifying exams such as the FRCS, MRCS, FAMS and FRANZCO. Clear, didactic chapters logically outline the requirements for Structured Vivas and Objective Structured Clinical Examination with ‘Do’s and Don’ts’ for each section. Viva and OSCE Exams in Ophthalmology: A Revision Study Guide fills the need for a study companion that contains all the required resources in a single usable guide for candidates sitting fellowship exams to become a registered ophthalmologist or surgeon. Ophthalmic specialist trainees, specialty doctors, staff grades, and associate specialists who wish to become a fellow will find this book to be an essential guide to revising for oral and clinical based exams in ophthalmology.
Biotransformation of Waste Biomass into High Value Biochemicals
Agro-industrial wastes are end-products emerging after industrial processing operations and also from their treatment and disposal e.g. solid fruit wastes and sludge. The agro-industrial wastes are often present in multiphase and comprise multicomponent. Nevertheless, these wastes are a goldmine as they possess valuable organic matter which can be diverted towards high value products ranging from polymers to antibiotics to platform chemicals. There have been plenty of books published on bioenergy, enzymes and organic acids, among others. However, this emerging field of biochemical has not yet been covered so far which is an important entity of the biorefinery model from waste biomass and needs to be understood from fundamental, applied as well as commercial perspective which has been laid out in this book.
