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Clinical trial design and endpoints in kidney transplantation
In 2018, the European Society for Organ Transplantation (ESOT) initiated a Broad Scientific Advice request to the European Medicines Agency (EMA), to discuss their Committee for Medicinal Products for Human Use (CHMP) guidelines relating to the development of innovative therapies in the field of kidney transplantation. The request suggested several options for redefining endpoints used in clinical studies of kidney transplantation. It also proposed study design elements for stratification and subsequent employment of these novel proposals into future clinical trials. The proposed endpoints also aimed to be suitable for the conditional marketing authorization pathway. The EMA subsequently evaluated the discussion document and evidence provided by ESOT, issuing their final recommendations in December 2020. This Special Issue of Transplant International provides a detailed summary of key aspects of the proposals and recommendations for definitions of endpoints for clinical trials of kidney transplantation.
Current Issues and Future Direction in Kidney Transplantation
The here presented book covers different areas of clinical and scientific interest, reaching from donor evaluation to newest methods in immunological diagnostics. But also aspects of daily care of transplant recipients can be found in the carefully selected chapters. Everything driven by the aim to improve the care for all of our transplanted patients.
Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the tran...
Obesity and Pregnancy
In this doctoral thesis, we identify socio-demographic, obstetrical and psychological characteristics of maternal obesity, we find evidence for beneficial outcomes of a lifestyle intervention programme in obese pregnant women, and we find support for longer term perinatal complications with postpartum weight retention between the first and second pregnancy.
New Insights into and Interventions of the Persistent Immune Responses in Chronic Graft Rejection, 2nd Edition
Publisher’s note: This is a 2nd edition due to an article retraction.
Long-Term Care of Kidney Transplant Patients
Long-term Care of Kidney Transplant Patients provides all aspects of long-term care of kidney transplant patients. Many of the chapters highlight unmet needs relevant to certain post-transplant events that influence survival. Chapters provide clinicians and researchers with opportunities to investigate and advance the science by performing studies than can alter the trajectory of specific post-transplant diseases which will improve long-term kidney survival further until we achieve "Transplant Tolerance."
Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Oxford Textbook of Clinical Nephrology
This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and...
Oxford Textbook of Clinical Nephrology
Illustrated in full colour throughout, this comprehensive edition provides the reader with complete information on clinical and practical problems in nephrology.
Symbiotic Association of Microorganisms with Medicinal and Herbal Plants
Research establishes that symbiotic association of microbes with medicinal and herbal plants enhance the growth and accumulation of bioactive materials, and that species of microbes including bacterial and fungal species play a key role. Symbiotic Association of Microorganisms with Medicinal and Herbal Plants identifies the important symbiotic association between microbes and medicinal plants, including perspectives in improving bioactive ingredients for the synthesis and preparation of pharmaceutical drugs. Features Provides a comprehensive overview of symbiotic association of microorganisms with medicinal and herbal plants Discusses the impacts of symbiotic association on the diversity, gr...
