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Dementia, Frailty and Aging
The number of older subjects is rapidly increasingly worldwide. As a consequence, the nature of clinical conditions is also changing. Traditional medicine and models of care have been based on the evaluation and treatment of single and usually acute conditions occurring in relatively young individuals. Today, the usual clinical manifestation of diseases is characterized by multiple and often chronic conditions affecting older people. In this scenario, frailty and dementia have been triggering special interest both in research and clinical settings due to their high prevalence, impact on the individual’s quality of life, and consequences for public health worldwide. These conditions aptly r...
Aging Research - Methodological Issues
This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care. The...
Novel Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.
Aging in multiple sclerosis: from childhood to old age, in women and men
In recent years attention has been drawn on changes in multiple sclerosis (MS) prevalence according to sex and age. We are now aware that MS is not a disease with onset exclusively in the young adult, but that pediatric cases are not infrequent, as well as onset in older adults. The need to assess the role of aging, sexual hormones, diet, and infections, has boosted research in many areas, from immunology to imaging techniques to psychology. An increasing awareness of the impact of MS on personal and sexual relationships, with the need to assess patient related outcomes also in clinical trials, has driven research not only in psychology, but in many other areas. The need to integrate information from all these different research areas is deeply felt.
Neurology of Sapienza
In the last two decades, Italian neurological research has experienced significant development, making a substantial contribution to the global cultural growth of Neurology. This Manual has been authored by neurologists from Sapienza University of Rome, who are experts in various fields of Neurology. Special attention has been given to diagnostic, clinical, and therapeutic aspects of different neurological disorders, including recent scientific advancements. The volume comprises 33 chapters covering topics in Neurology, Neuroradiology, and Neurosurgery, including a chapter on Neurorehabilitation, one on Pediatric Neurology, and one on Principles of Psychiatry. The Manual serves as a valuable tool for medical students, including those pursuing healthcare professions, as well as Neurology residents. It dedicates ample space to symptoms of potential neurological origin encountered in general clinical practice and the neurological conditions that clinicians must be familiar with.
Neurology in Migrants and Refugees
This book is the result of reflections and work of the Specialty group on neurology in migrants of the World Federation of Neurology. The volume provides a synthesis of migrants’ health in relation to the sustainable development goals and the 2030 agenda, and an up-to-date overview on neurological diseases among migrants, refugees and ethnic minorities. The book is composed of both general chapters dealing with the history of migration, the relationship between climate change and migration flows, the migration and neurosciences research and the barriers to migrant’s health. Other chapters deal with the migrants' particularities of the common neurological diseases such as cerebrovascular ...
Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.B)
Volume I.B An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international ...
