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The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field.
Notable contribucion a un mas amplio conocimiento y comprension de las modalidades especificas que en diversas etapas y regiones adopto la hacienda en nuestro pais, asi como de su funcionamiento. Han sido delimitados tres ambitos o niveles de analisis, a saber: la hacienda en Mexico, la hacienda en el altiplano de Puebla-Tlaxcala y el estudio monografico de la hacienda de San Jose Ozumba en Puebla.
This volume contains a selection of nineteen peer-reviewed papers from the 40th annual Linguistic Symposium on Romance Languages (LSRL) held at the University of Washington in March 2010. In addition to overviews of Romance linguistics by the editor and by Jurgen Klausenburger in the keynote article, contributions cover a variety of linguistic theoretical topics and a range of Romance languages, including Old and Modern French, Italian, Romanian as well as several dialects of Spanish and Portuguese. A number of papers deal with the morphophonology of Peninsular Spanish languages, agreement anomalies, generic interpretation, and the syntax/semantics of determiners, particularly of Romanian. Both the topics and the languages discussed in this volume are tied together by a number of leitmotifs, and several articles present phenomena not previously considered. The volume makes significant contributions both to the documentation of Romance languages and to linguistic theory, and will be of interest to Romance and general linguistics scholars.
The Lloyd's Register of Shipping records the details of merchant vessels over 100 gross tonnes, which are self-propelled and sea-going, regardless of classification. Before the time, only those vessels classed by Lloyd's Register were listed. Vessels are listed alphabetically by their current name.
How do schools worldwide treat the Holocaust as a subject? In which countries does the Holocaust form part of classroom teaching? Are representations of the Holocaust always accurate, balanced and unprejudiced in curricula and textbooks? This study, carried out by UNESCO and the Georg Eckert Institute for International Textbook Research, compares for the first time representations of the Holocaust in school textbooks and national curricula. Drawing on data which includes countries in which there exists no or little information about representations of the Holocaust, the study shows where the Holocaust is established in official guidelines, and contains a close textbook study, focusing on the comprehensiveness and accuracy of representations and historical narratives. The book highlights evolving practices worldwide and thus provides education stakeholders with comprehensive documentation about current trends in curricula directives and textbook representations of the Holocaust. It further formulates recommendations that will help policy-makers provide the educational means by which pupils may develop Holocaust literacy.