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Diabetes
Diabetes: Oxidative Stress and Dietary Antioxidants, Second Edition, builds on the success of the first edition, covering updated research on the science of oxidative stress in diabetes and the potentially therapeutic usage of natural antioxidants in the diet and food matrix. The processes within the science of oxidative stress are not described in isolation, but rather in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. Since the publication of the first edition, the science of oxidative stress and free radical biology continues ...
Diabetes
Diabetic retinopathy (DR) is the leading cause of acquired blindness in working age adults worldwide. Biochemical changes in DR contribute to both the microscopic structural and functional changes in the retina. All these alterations result in macroscopic retinal damage that can be assessed by funduscopy. The overproduction of reactive oxygen species (ROS) in the mitochondria is considered a causal link between elevated glucose and biochemical abnormalities in the pathophysiology of DR. Moreover, oxidatively induced pathways also seem to provide positive feedback to ROS production, resulting in a vicious cycle. ROS can directly damage lipids, proteins and DNA, leading to cell death. To make the situation worse, antioxidant defenses are also impaired in diabetes. Otherwise, ROS are involved in the production of inflammatory cytokines and growth factors such as interleukins or vascular endothelial growth factor (VEGF). In addition, ROS not only contribute to the development of DR, but also play a role in its progression when the hyperglycemic insult is controlled. This phenomenon is called metabolic memory.
Metal Nanocomposites in Nanotherapeutics for Oxidative Stress-Induced Metabolic Disorders
This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's di...
Handbook of Nutrition, Diet, and the Eye
The Handbook of Nutrition, Diet and the Eye is the first book to thoroughly address common features and etiological factors in how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss can be devastating. One of the biggest contributors to complete vision loss in the western hemisphere is diabetes, precipitated by metabolic syndrome. In some developing countries, micronutrient deficiencies are major contributory factors to impaired vision. However, there are a range of ocular defects that have either their origin in nutritional deficiencies or excess or have been shown to respond...
A síndrome metabólica e suas implicações clínicas
A síndrome metabólica é uma desordem complexa de base genética e origem multifatorial. O livro, que traz resultado de várias pesquisas de pós-graduação, trata desse sério problema de saúde que atinge muitas pessoas e é essencial para profissionais de saúde de todas as áreas, mas principalmente nutrição e medicina.
Atlas of Anterior Segment Optical Coherence Tomography
Part of the Essentials in Ophthalmology series, this atlas is designed to comprehensively cover optical coherence tomography of the anterior segment of the eye. The aim is to improve knowledge of the fundamentals of OCT technology for anterior segment, clarify the differences with posterior segment OCT and emphasize the immense relevance and usefulness that anterior segment OCT study has for diagnosis, therapeutic orientation, surgical guidance, and improvement in patient management. Atlas of Anterior Segment Optical Coherence Tomography is organized into comprehensive chapters on the following topics: fundamentals, technologies and technological differences among platforms, application of O...
