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Bone Marrow T Cells at the Center Stage in Immunological Memory
Increasing evidence supports the notion that bone marrow (BM) represents a relevant player in T cell responses, particularly in its role as a specialized organ for long-term memory. Memory T cells are enriched in the BM over long times after priming, and can be recruited to the periphery upon antigenic challenge. The articles in this research topic include discussions of whether these T cells are passing-through or truly resident, as well as a debate on the extent of proliferation of BM memory T cells. Original research articles in this collection include an analysis of the number of memory T cells found in different bones as well as effects of B cell depletion on T cell memory in the BM. T cells in the BM can influence a number of processes, from bone remodeling, control of cancer, to effects on hemopoiesis or Graft versus Host Disease (GVHD). This research topic contains several contributions to these topics including discussions on how to translate BM T cell knowledge into medicine.
Advances in Bioinformatics and Computational Biology
This book constitutes the refereed proceedings of the Third Brazilian Symposium on Bioinformatics, BSB 2008, held in Sao Paulo, Brazil, in August 2008 - co-located with IWGD 2008, the International Workshop on Genomic Databases. The 14 revised full papers and 5 extended abstracts were carefully reviewed and selected from 41 submissions. The papers address a broad range of current topics in computational biology and bioinformatics featuring original research in computer science, mathematics and statistics as well as in molecular biology, biochemistry, genetics, medicine, microbiology and other life sciences.
Heteroptera of Economic Importance
Heteropterans regularly cause a wide variety and large number of problems for humans - at times on a catastrophic scale. The 37,000 described species of this suborder including many pests, disease transmitters, and nuisances exist worldwide, inflicting damage on crops, forests, orchards, and human life. Inspired by the widespread economic impact of
Marine Cyanobacteria
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The Little Book of Tom. Military Men
Stand at attention with this pocket-sized army of free, proud, masculine fantasy men committed to pleasure and male camaraderie. With multi-panel comics and single-panel drawings and paintings, as well as personal photographs and sketches, The Little Book of Tom: Military Men celebrates the artist's most iconic vision of masculine perfection.
Protein Simulations
Protein Simulation focuses on predicting how protein will act in vivo. These studies use computer analysis, computer modeling, and statistical probability to predict protein function. * Force Fields* Ligand Binding* Protein Membrane Simulation* Enzyme Dynamics* Protein Folding and unfolding simulations
Free Energy Calculations
Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of th...
Human Virology
This is the second edition of a well received textbook which was originally published in 1993. The new edition includes major revisions in certain chapters, and integrates the interface between science and medicine more than it did previously. There is also more discussion on clinically important conditions. The bright, bold format, from the first edition has been kept, but has been given a more sophisticated and up-to-date look. Virology, perhaps more than any other discipline, playsan extremely important role in the advances of biomedical research. New discoveries are continually being made, and their subsequent application to the relief of suffering proceed at an ever-increasing pace. Vir...
