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Multiple Myeloma
This book deals with the diagnosis and treatment of multiple myeloma. Multiple myeloma is a plasma cell disorder, the prognosis of which has dramatically improved in the last years thanks to new immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies, in relapsed/refractory disease and a diagnosis. Chapters cover such topics as prognostic and predictive factors in newly diagnosed multiple myeloma, treatment approaches, antibody therapies, and three-dimensional (3D) models mimicking multiple myeloma bone marrow–microenvironment interactions.
Women in Cytokines and Soluble Mediators in Immunity
We are delighted to present the inaugural Frontiers in Immunology “Women in Cytokines and Soluble Mediators in Immunity” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and Science, Technology, Engineering and Mathematics (STEM) research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
Lost Girls
In 1554, a group of idealistic laywomen founded a home for homeless and orphaned adolescent girls in one of the worst neighborhoods in Florence. Of the 526 girls who lived in the home during its fourteen-year tenure, only 202 left there alive. Struck by the unusually high mortality rate, Nicholas Terpstra sets out to determine what killed the lost girls of the House of Compassion shelter (Casa della Pietà). Reaching deep into the archives' letters, ledgers, and records from both inside and outside the home, he slowly pieces together the tragic story. The Casa welcomed girls in bad health and with little future, hoping to save them from an almost certain life of poverty and drudgery. Yet thi...
Novel Aspects in Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of e...
Ottaviano Petrucci
The innovative work in design, typography, and content of music printer and publisher Ottaviano Petrucci (1446-1539) became the standard by which all following printers measured themselves. He created the defining moment when Italy took the lead in book printing in the Renaissance.This book is a bibliographic study of the output of the Petrucci presses, laying emphasis on the professional career of Petrucci. It includes a detailed study of technique and house-style, examining the market forces that drove Petrucci's publishing decisions, and provides a detailed catalogue of editions and copies.Stanley Boorman has made a study of the output of Petrucci's presses for 25 years. This long-awaited contribution to the field of bibliography will have an audience both in music and in rare book bibliography.
The Lancet
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