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Recent Advances in QSAR Studies
This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.
Computational Approaches for Identifying Drugs Against Alzheimer's Disease
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
8th AF News
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Doesn't Time Fly?
A book that charts the history of Aer Lingus up to its 75th anniversary, celebrated in 2011.
Poverty and Inclusion in Early Years Education
Poverty and Inclusion in Early Years Education will help practitioners to understand the experiences of young children who are living in poverty. It examines the potentially devastating impact of poverty and social exclusion on children’s chances in later life, and considers recent policy and practice reforms which have recognised the critical role played by early years settings and practitioners in guaranteeing a secure foundation for children’s future attainment. The book explores the historical, political and legal aspects of policy on poverty and social exclusion, before offering guidance on how practitioners can help to address the inequalities caused by poverty and break the cycle ...
Genetic Polymorphisms and Susceptibility to Disease
Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, oncology, cardiology and immunology . In addition, this book serves as a primer for students first entering the field of genetic research.
Last Orgy of the Divine Hermit
A brilliant and utterly original new novel from Mark Leyner about a father and his intense and devout relationship with his daughter and with alcohol. An anthropologist and his daughter travel to Kermunkachunk, the capitol of Chalazia, to conduct research for an ethnography on the Chalazian Mafia Faction (a splinter group of the Chalazian Children's Theater). The book takes place over the course of a night at the Bar Pulpo, Kermunkachunk's #1 spoken-word karaoke bar, where conversations are actually being read from multiple karaoke screens arrayed around the barroom. Moreover, it's Thursday, "Father/Daughter Nite," when the bar is frequented by actual fathers and daughters as well as couples cosplaying fathers and daughters. Last Orgy of the Divine Hermit is a book about the deep pleasures of reading and drinking, the tumultuous reign of a cabal of mystic mobsters, and, of course, the transcendent love of a father for his daughter.
The City Record
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