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RADIANCE - Radiochemotherapy with Or Without Durvalumab in the Treatment of Anal Squamous Cell Carcinoma: a Randomized Multicenter Phase II Trial
Abstract: Purpose Anal squamous cell carcinomas (ASCC) are increasing in frequency across the developed world. The 3-year disease-free survival (DFS) in patients with locally-advanced disease is approximately 60% after primary radiochemotherapy (RCT). There is a strong rationale for combining immunotherapy with RCT in patients with ASCC due to its association with human papilloma virus (HPV) infection. Methods/design RADIANCE is an investigator initiated, prospective, multicenter, randomized phase II trial testing the addition of Durvalumab, a PD-L1 immune checkpoint inhibitor, to standard RCT in 178 patients with locally advanced ASCC (T2 ≥ 4 cm Nany, cT3-4 and/or cN+). In the control arm...
NK Cell-Based Cancer Immunotherapy
Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D...
A Dictionary of German-Jewish Surnames
This dictionary identifies more than 13,000 German-Jewish surnames from the area that was pre-World War I Germany. From Baden-Wuerttemburg in the south to Schleswig-Holstein in the north. From Westfalen in the west to East Prussia in the east. In addition to providing the etymology and variants of each name, it identifies where in the region the name appeared, identifying the town and time period. More than 300 sources were used to compile the book. A chapter provides the Jewish population in many towns in the 19th century.
Gerhart Hauptmann
Der Streit um die Weber machte ihn zum bekanntesten Deutschen seiner Generation: Gerhart Hauptmanns (1862–1946) Ruhm überdauerte den Zweiten Weltkrieg und sicherte noch dem Verstorbenen eine Ausreise per Sonderzug aus dem inzwischen polnischen Schlesien sowie die Beteiligung führender SED-Politiker an der Bestattung auf Hiddensee. Die erste konsequent aus Originalquellen gespeiste Biographie erzählt die erstaunliche Erfolgsgeschichte des Gastwirtssohns aus dem schlesischen Salzbrunn, der auszog, um Monumentalbildhauer zu werden, und als größter Dramatiker des Naturalismus in die Literaturgeschichte einging. Seinem Ruf als moralische Autorität, ja als Gewissen der Nation ist der Nobel...
The Complete Knight's Cross
The Knight's Cross of the Iron Cross, to give it its full name, owes its origins to the Pour le Merite (Blue Max), an imperial award dating back to 1740. The Complete Knight's Cross is the only book to tell the story of all 7,364 men who were awarded it (including all the disputed awards). The book has over 200 photos of holders of the medal and over 100 photos of their graves. Volume One deals with 1939-41 (numbers 1-1267) and is subtitled The Years of Victory. Volume Two deals with 1942-43 (numbers 1268-3685) and is subtitled The Years of Stalemate. Volume Three deals with 1944-45 (numbers 3686-7364) and is subtitled The Years of Defeat. The recipients are listed in the order of the date of award. Each entry starts with the recipients rank and name, followed by details of the action or actions for witch they were awarded it. Other interesting facts and stories are also included for many of them. Finally their burial locations, where known are given. Any higher awards (Oak Leaves, Swords, Diamonds and the ultimate Golden award) are also covered.
