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RADIANCE - Radiochemotherapy with Or Without Durvalumab in the Treatment of Anal Squamous Cell Carcinoma: a Randomized Multicenter Phase II Trial
Abstract: Purpose Anal squamous cell carcinomas (ASCC) are increasing in frequency across the developed world. The 3-year disease-free survival (DFS) in patients with locally-advanced disease is approximately 60% after primary radiochemotherapy (RCT). There is a strong rationale for combining immunotherapy with RCT in patients with ASCC due to its association with human papilloma virus (HPV) infection. Methods/design RADIANCE is an investigator initiated, prospective, multicenter, randomized phase II trial testing the addition of Durvalumab, a PD-L1 immune checkpoint inhibitor, to standard RCT in 178 patients with locally advanced ASCC (T2 ≥ 4 cm Nany, cT3-4 and/or cN+). In the control arm...
A Patterns of Care Analysis of Hyperthermia in Combination with Radio(chemo)therapy Or Chemotherapy in European Clinical Centers
Abstract: Purpose The combination of hyperthermia (HT) with radio(chemo)therapy or chemotherapy (CT) is an established treatment strategy for specific indications. Its application in routine clinical practice in Europe depends on regulatory and local conditions. We conducted a survey among European clinical centers to determine current practice of HT. Methods A questionnaire with 22 questions was sent to 24 European HT centers. The questions were divided into two main categories. The first category assessed how many patients are treated with HT in combination with radio(chemo)therapy or CT for specific indications per year. The second category addressed which hyperthermia parameters are reco...
MR Linac Radiotherapy
MR Linac Radiotherapy: A New Personalized Treatment Approach comprises both clinical and physical aspects of this new technology. The book covers treatment planning, workflow and technical issues about MR-Linac. Specially, the clinical use of MR-Linac according to different cancer types is presented by experienced physicians. This is a unique guide for medical physicists, RTTs, dosimetrists and physicians, as well as radiation oncologists and their teams. The MR Linac combines two technologies - a magnetic resonance imaging scanner and a linear accelerator - to precisely locate tumors, tailor the shape of radiation beams in real-time, and precisely deliver doses of radiation, even to moving tumors. This highly innovative technology is very new, and the number of newly installed MR-Linac machines will gradually increase worldwide. However, as there is no published book as a guideline, this book will help new MR-Linac users and centers planning to have MR-Linac. Presents the first book on MR Linac Radiotherapy Comprises both clinical and physical aspects of this new technology Written by leading editors and authors in the field
Birinci Cihan Harbindeki Hayatım
1914, 1. Cihan harbinde SARIKAMIŞ VE KAFKAS CEPHESİ’ne katılan Müderris Halil Hilmi KALAYCIOĞLU’nun cephede kaleme aldığı anılarından derlenen bu eserde; askere nasıl alındıkları, Erzincan’daki birliğine katıldıktan sonra şiddetli kış mevsimi ile birlikte sınırımızı geçen Ruslarla yapılan Sarıkamış muharebesinin acı neticelerini, Osmanlı ordularındaki unsurlarından olan Ermenilerin firar edip Ruslara katılmasının doğurduğu acı sonuçları, Erzurum’un ve Erzincan’ın kaybedilişi. Fırat boyunda Kemah’a kadar çekilen birliklerimizin toparlanıp kaybedilen şehir ve ilçelerimizi yeniden vatan topraklarına katmasını, Bolşevik ihtilali ile birlikte dağılan Rus ordusunu destekçisi olan Ermenilerle birlikte sınırdan öteye atmasını, İran üzerinden Rus ve Ermenilere desteğe gelen İngiliz ordusuna da gereken dersi verip Ermenistan’ı üç günde fethedip Bakü’yü de Rus işgalinden kurtarılmasını sanki bir aksiyon filmi izler gibi okuyacaksınız.
