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Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evalu...
Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better un...
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“A fascinating journey [with] a few salient conclusions: primarily that we’d all be a lot better off if we ate like our great-great-great grandparents.” —National Post There are few areas of modern life that are as burdened by information and advice, often contradictory, as our diet and health. In 100 Million Years of Food, biological anthropologist Stephen Le explains how cuisines of different cultures are a result of centuries of evolution, finely tuned to our biology and surroundings. Travelling around the world to places as far-flung as Vietnam, Kenya, India, and the US, Stephen Le introduces us to people who are growing, cooking, and eating food using both traditional and modern...
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and ep...
This book provides a complete Phanerozoic story of palaeogeography, using new and detailed full-colour maps, to link surface and deep-Earth processes.
It is the purpose of this publication to assist those interested in medicinal plant identification and to furnish other useful information in connection with the work.
This book constitutes the refereed proceedings of the 22nd IFIP WG 6.1 International Conference on Formal Techniques for Networked and Distributed Systems, FORTE 2002, held in Houston, Texas, USA in November 2002. The 22 revised full papers, 2 tool papers, and 2 posters presented were carefully reviewed and selected from 61 submissions. All current aspects of formal method for distributed systems and communication protocols are addressed, in particular formal specification, testing, and verification of such systems.
Metamorphic rocks are one of the three classes of rocks. Seen on a global scale they constitute the dominant material of the Earth. The understanding of the petrogenesis and significance of metamorphic of geological education. rocks is, therefore, a fundamental topic There are, of course, many different possible ways to lecture on this theme. This book addresses rock metamorphism from a relatively pragmatic view point. It has been written for the senior undergrad uate or graduate student who needs practical knowledge of how to interpret various groups of minerals found in metamorphic rocks. The book is also of interest for the non-specialist and non-petrolo gist professional who is intereste...