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Practising evidence-based medicine necessarily depends on the clinician having access to the best evidence available, but in a fast-moving field, keeping up to date with the latest developments is a challenging prospect. In this new volume, leading experts focus on the most important clinical issues associated with the management of lipid disorders, evaluating and interpreting the evidence available to provide the reader with a reliable summary of our current knowledge. Topics covered include therapeutical strategies for managing hereditary lipid disorders, including familial hypercholesterolemia, both in adults and children, and familial combined hypercholesterolemia. The authors also evalu...
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Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better un...
A fascinating tour through the evolution of the human diet and how we can improve our health by understanding our complicated history with food. There are few areas of modern life that are burdened by as much information and advice, often contradictory, as our diet and health: eat a lot of meat, eat no meat; whole grains are healthy, whole grains are a disaster; eat everything in moderation; eat only certain foods--and on and on. In 100 Million Years of Food, biological anthropologist Stephen Le explains how cuisines of different cultures are a result of centuries of evolution, finely tuned to our biology and surroundings. Today many cultures have strayed from their ancestral diets, relying instead on mass-produced food often made with chemicals that may be contributing to a rise in so-called Western diseases, such as cancer, heart disease, and obesity.
It is the purpose of this publication to assist those interested in medicinal plant identification and to furnish other useful information in connection with the work.
This book provides a complete Phanerozoic story of palaeogeography, using new and detailed full-colour maps, to link surface and deep-Earth processes.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and ep...
A complete starting package for students and researchers of the earth science community interested in numerical modeling of microstructures. This excellent book deals with the numerical simulation of such microstructures in rocks. It starts with an introduction to existing methods and techniques for optical and electron microscopic analysis. The main part of the book contains examples of numerical modeling of processes and microstructures in rocks, using the software package "ELLE".
This book constitutes the refereed proceedings of the 22nd IFIP WG 6.1 International Conference on Formal Techniques for Networked and Distributed Systems, FORTE 2002, held in Houston, Texas, USA in November 2002. The 22 revised full papers, 2 tool papers, and 2 posters presented were carefully reviewed and selected from 61 submissions. All current aspects of formal method for distributed systems and communication protocols are addressed, in particular formal specification, testing, and verification of such systems.