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Brain Glycogen Metabolism
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.
Proceedings of the International School on Magnetic Resonance and Brain Function - XII Workshop
In the last thirty years, Magnetic Resonance has generated a wide revolution in biomedical research and in medical imaging in general. More recently, the "in vivo" studies of the human brain were extended by new original ways to the dynamic study of function and metabolism of the human brain. The enormous interest in expanding the investigation of the brain is emphasizing the search for new NMR methods capable of extracting information of so-far obscure aspects of the brain function. In fact, many quantitative approaches have been proposed in order to complement the information obtained by functional MRI, and several multimodal and multiparametric approaches have been developed to exploit th...
Origins of the Resting-State fMRI Signal
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Astrocytic-neuronal-astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA
Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany).
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New Perspectives on Generalized Anxiety Disorder
Generalized Anxiety Disorder may be seen as a gateway condition from normalcy to pathology with blurred boundaries towards several concurrent disorders. This anxiety illness is responsible for psychological suffering and personal dysfunction in a considerable proportion of individuals in the general population. Since its original definition in the DSM-III (1980), the clinical and scientific interest in Generalized Anxiety Disorder has grown, becoming a challenge for researchers and practitioners nowadays. This book provides a modern viewpoint with intriguing insights on relevant topics, including historical frameworks, epidemiology, basic neurobiological sciences, clinical presentation and complexity, and major treatment options. The list of contributors include professors, researchers, PhD students, clinical psychiatrists and psychologists; they belong to different universities and training institutions and all of them possess a distinguished expertise in the specific fields of interest. Psychiatrists, physicians, psychologists, residents and undergraduate students may take advantage of this book, from both clinical and research-oriented perspectives.
A Sense of Urgency
A study of how the climate crisis is changing human communication from a celebrated rhetorician. Why is it difficult to talk about climate change? Debra Hawhee argues that contemporary rhetoric relies on classical assumptions about humanity and history that cannot conceive of the present crisis. How do we talk about an unprecedented future or represent planetary interests without privileging our own species? A Sense of Urgency explores four emerging answers, their sheer novelty a record of both the devastation and possible futures of climate change. In developing the arts of magnitude, presence, witness, and feeling, A Sense of Urgency invites us to imagine new ways of thinking with our imperiled planet.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Brain Energy Metabolism
Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
