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Vitamin D and Cancer
Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.
The Persianate World
At publication date, a free ebook version of this title will be available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. Persian is one of the great lingua francas of world history. Yet despite its recognition as a shared language across the Islamic world and beyond, its scope, impact, and mechanisms remain underexplored. A world historical inquiry into pre-modern cosmopolitanism, The Persianate World traces the reach and limits of Persian as a Eurasian language in a comprehensive survey of its geographical, literary, and social frontiers. From Siberia to Southeast Asia, and between London and Beijing, this book shows how Persian gained, maintained, and finally surrendered its status to imperial and vernacular competitors. Fourteen essays trace Persian’s interactions with Bengali, Chinese, Turkic, Punjabi, and other languages to identify the forces that extended “Persographia,” the domain of written Persian. Spanning the ages expansion and contraction, The Persianate World offers a critical survey of both the supports and constraints of one of history’s key languages of global exchange.
Hydrogels
This book discusses recent advances in hydrogels, including their generation and applications and presents a compendium of fundamental concepts. It highlights the most important hydrogel materials, including physical hydrogels, chemical hydrogels, and nanohydrogels and explores the development of hydrogel-based novel materials that respond to external stimuli, such as temperature, pressure, pH, light, biochemicals or magnetism, which represent a new class of intelligent materials. With their multiple cooperative functions, hydrogel-based materials exhibit different potential applications ranging from biomedical engineering to water purification systems. This book covers key topics including ...
Eurasian Economies
This volume explores the economies of countries in Asia, as well as the former Soviet socialist bloc countries of Central Asia and the Balkans. It analyses the region from the perspective of globalization and regional economic integration, economic growth and sustainable development, international trade and finance, money market and banking systems, labor market and external migration, energy and agricultural sectors. This book will appeal to anyone who is interested in economies of this region, their transition process towards a market economy regime, and their integration in the global world, including academicians from any field of social sciences, as well as decision makers, politicians, businessmen and journalists.
Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance
Fluid, electrolyte, and acid-base disorders are central to the day-to-day practice of almost all areas of patient-centered medicine – both medical and surgical. Virtually every aspect of these disorders has experienced major developments in recent years. Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance encompasses these new findings in comprehensive reviews of both pathophysiology and clinical management. In addition, this volume offers clinical examples providing step-by-step analysis of the pathophysiology, differential diagnosis, and management of selected clinical problems. Written by leading experts in fluid, electrolyte, and acid-base disorders, this reference is an invaluable resource for both the nephrologist and the non-specialist physician, or medical trainee.
Scher and Daniel's Nails
This thoroughly updated 4th Edition of this highly regarded text continues to provide the latest therapeutic and surgical information on nail disease and disorders. It expands and updates all areas of onychology, including the newest in diagnostic techniques for nail diseases, a segment of dermatology that not only proves more difficult than cutaneous disorders but also is an exciting and innovative area on the frontier of skin research. Scher and Daniel's Nails: Diagnosis, Surgery, Therapy provides an update of therapeutic advances to help the resident, practitioner, and related healthcare provider (podiatrist, nurse, primary care physician, and all involved in nail care). A major section is devoted to nail surgery and nail pathology, both of which have been behind compared to other aspects of dermatology. There is also extensive information on the billion dollar nail cosmetics industry, which will bring this text to the attention of all nail technicians (several hundred thousand in the US alone) as well as to cosmeticians and manufacturers.
Myofibrillogenesis
Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult t...
Anthocyanins in Fruits, Vegetables, and Grains
This text is a comprehensive reference covering the chemistry, physiology, chemotaxonomy, biotechnology and food technology aspects of the anthocyanins. Topics discussed include types of anthocyanins, structural transformations, colour stabilization and intensification factors, biosynthesis and intensification factors, biosynthesis, analysis and functions of anthocyanins. An in-depth review of the literature discussing anthocyanins of fruits, cereals, legumes, roots, tubers, bulbs, cole crops, oilseeds, herbs, spices, and minor crops is included as well
