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Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials
This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design,...
Planning and Analyzing Clinical Trials with Composite Endpoints
This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical tri...
Quantitative Research Methods in Translation and Interpreting Studies
Quantitative Research Methods in Translation and Interpreting Studies encompasses all stages of the research process that include quantitative research methods, from conceptualization to reporting. In five parts, the authors cover: • sampling techniques, measurement, and survey design; • how to describe data; • how to analyze differences; • how to analyze relationships; • how to interpret results. Each part includes references to additional resources and extensive examples from published empirical work. A quick reference table for specific tests is also included in the appendix. This user-friendly guide is the essential primer on quantitative methods for all students and researchers in translation and interpreting studies. Accompanying materials are available online, including step-by-step walkthroughs of how analysis was conducted, and extra sample data sets for instruction and self study: https://www.routledge.com/9781138124967. Further resources for Translation and Interpreting Studies are available on the Routledge Translation Studies Portal: http://cw.routledge.com/textbooks/translationstudies.
Design and Analysis of Cross-Over Trials, Third Edition
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that addr...
Disruptive Behavior
Disruptive behavior is extremely common in normal and clinical populations. This book addresses its development, the newly grouped diagnoses associated with it and their bio-psycho-social causes and treatment. The past decade has seen a great deal of progress in the psychiatric and psychological literature, which has greatly advanced our understanding of these disorders. The book discusses state of the art studies of taxonomy, epidemiology, etiology, and treatment. Each chapter concludes with a thorough discussion of the clinical implications of this new information, exemplified by real case material. A whole chapter is devoted to the forensic implications of this important grouping of disor...
Informatics, Management and Technology in Healthcare
Biomedical informatics is becoming increasingly important as healthcare organizations worldwide implement biomedical informatics applications as part of their continued effort to improve the effectiveness of patient care and the efficiency of service delivery. This book presents the full papers delivered at the 2013 International Conference on Informatics, Management and Technology in Healthcare (ICIMTH 2013), held in Athens, Greece, in July 2013. The scope of biomedical informatics is very broad, including a number of technologies such as imaging, sensors, biomedical equipment and even organ transplant technology. The 90 papers included here examine research and applications outcomes - from cell to population - in these diverse fields, and because management and organizational issues play an important role in the implementation phase of biomedical informatics applications, these topics are also covered as an integral part of the theme. The book will be of interest to all those whose work involves the development and use of biomedical informatics applications.
Developments in Statistical Evaluation of Clinical Trials
This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.
